不同中子能量在硼中子俘获治疗中到达健康组织的光子剂量的研究

IF 0.9 4区 工程技术 Q3 NUCLEAR SCIENCE & TECHNOLOGY Nuclear Technology & Radiation Protection Pub Date : 2022-01-01 DOI:10.2298/ntrp2204334t
T. Tuğrul
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引用次数: 0

摘要

硼中子俘获疗法是一种独特的治疗方法,旨在借助重粒子杀死肿瘤细胞。含有10B原子的肿瘤区域与热中子或超热中子相互作用产生的粒子在这种治疗方法中起着最重要的作用。本研究研究了10B(n,a)7Li反应产生的伽马辐射到达健康组织的情况。利用蒙特卡罗n粒子(MCNP)程序建立了一个适用于硼中子俘获治疗的模拟模型,包括人体头部模型。利用五种不同的中子能量,研究了10B(n,a)7Li反应在靠近肿瘤组织的确定区域产生的伽马辐射。据观察,肿瘤区域和表面之间的健康组织暴露于最高的伽马通量和最高的伽马辐射吸收。还观察到这些值随着中子能量的降低而增加。结果发现,中子辐照区以外的某些地区所受的伽马剂量可能很大。据了解,中子能量的变化可能引起到达健康组织的伽马辐射值的显著变化,特别是在接近表面的区域。在硼中子俘获治疗中,送入肿瘤的中子应根据肿瘤的位置和肿瘤区域的大小来选择。本研究包含了使用不同中子能量的硼中子俘获治疗技术治疗脑区周围健康组织的光子剂量的重要数据。
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Investigation of photon doses reaching healthy tissues in the use of different neutron energies in boron neutron capture therapy
Boron neutron capture therapy is a unique treatment method that aims to kill the tumor cells with the help of heavy particles. Particles resulting from the interaction of the tumor region containing 10B atoms with thermal or epithermal neutrons have the most important role in this treatment method. In this study, gamma radiation reaching healthy tissues, which is the result of 10B(n,a)7Li reaction, was investigated. A simulation suitable for boron neutron capture therapy treatment, including the human head model, was created by the Monte Carlo N-Particle (MCNP) program. By using five different neutron energies, the gamma radiations resulting from the 10B(n,a)7Li reaction in the determined regions, close to the tumor tissue, were investigated. It was observed that the healthy tissue between the tumor area and the surface is exposed to the highest gamma flux and the highest gamma radiation absorption. It was also observed that these values increase as neutron energy decreases. It was found that the gamma doses received by some regions outside the neutron irradiation area could be significant. It has been understood that the change in neutron energy may cause significant changes in gamma radiation values reaching healthy tissues, especially in regions close to the surface. In boron neutron capture therapy treatments, the neutrons sent to the tumor should be selected depending on the location of the tumor and the size of the tumor area. This study contains significant data about photon doses in healthy tissues around the brain region treated using different neutron energies with the boron neutron capture therapy technique.
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来源期刊
Nuclear Technology & Radiation Protection
Nuclear Technology & Radiation Protection NUCLEAR SCIENCE & TECHNOLOGY-
CiteScore
2.00
自引率
41.70%
发文量
10
审稿时长
6-12 weeks
期刊介绍: Nuclear Technology & Radiation Protection is an international scientific journal covering the wide range of disciplines involved in nuclear science and technology as well as in the field of radiation protection. The journal is open for scientific papers, short papers, review articles, and technical papers dealing with nuclear power, research reactors, accelerators, nuclear materials, waste management, radiation measurements, and environmental problems. However, basic reactor physics and design, particle and radiation transport theory, and development of numerical methods and codes will also be important aspects of the editorial policy.
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