家鼠抗凝血药耐药性的筛选与预防研究进展

T. Blažić, Goran Jokić, Suzana Djedovic
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引用次数: 1

摘要

无限制地使用抗凝血剂已导致啮齿动物对抗凝血剂产生耐药性。这在减少啮齿动物数量方面造成了一系列问题,进一步造成了巨大的经济损失,并严重威胁到人和家畜的健康。目前全球流行的趋势是通过使用尽可能少的化学品来控制啮齿动物的数量,另一方面,这意味着需要采用几种协同的替代措施,以努力将啮齿动物的数量减少到可接受的经济水平。另一方面,了解啮齿动物种群的遗传结构已成为在实际使用灭鼠剂之前需要掌握的一组重要信息,以防止灭鼠剂的无效使用,防止耐药啮齿动物种群的进一步传播。使用低剂量抗凝诱饵组合的最新趋势需要进一步研究,因为它们对易感人群的影响是已知的,但对耐药动物的影响仍不清楚。
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Screening and prevention of anticoagulant resistance development in house mice: A review
Unrestricted use of anticoagulants has resulted in rodents developing resistance to them. This has caused a series of problems regarding reduction in rodent populations, which has further implicated great economic losses and a serious threat to the health of people and domestic animals. The popular global trend currently is to control rodent populations by applying the least possible amounts of chemicals, which on the other hand implies that several coactive alternative measures need to be applied in an effort to reduce rodent numbers to an acceptable economic level. On the other hand, knowledge of the genetic structure of rodent populations has become an important set of information desirable to have before setting off to apply rodenticides in practice, so as to prevent ineffective use of rodenticides and prevent further spreading of resistant rodent populations. The latest trend of using combinations of low-dose anticoagulant baits requires further research as their effects on susceptible populations are known but their impact on resistant animals is still not clear.
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