氧化应激反应作为淡水无脊椎模式生物(Unio mancus Lamarck, 1819)暴露于防污铜吡硫酮的生物标志物

Elif Paçal, Aşkım Gümüş, Çağlan Günal, B. Erkmen, P. Arslan, Z. Yildirim, F. Erkoç
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引用次数: 2

摘要

利用氧化应激参数和组织病理学评估了硫硫铜(CuPT)对无脊椎模式生物淡水贻贝(Unio mancus)的亚致死效应。以环境相关浓度5.5 g/l的硫代铜为半静态暴露96 h。与对照组相比,消化腺(DG) MDA水平显著升高(p < 0.001)。鳃丙二醛水平也显著升高,但差异不显著(p < 0.05)。DG中GSH水平显著升高(p 0.05)。SOD、GPx活性、AOPP水平无显著变化(p < 0.05)。鳃中最显著的组织病理学改变是血细胞浸润、脂褐素聚集和片层变形伴小管变性和脂褐素聚集在DG小管中。CuPT影响抗氧化防御系统,即使在亚致死暴露的Unio mancus作为淡水模式生物。
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Oxidative stress response as biomarker of exposure of a freshwater invertebrate model organism (Unio mancus Lamarck, 1819) to antifouling copper pyrithione
Sublethal effects of copper pyrithione (CuPT) on an invertebrate model organism, freshwater mussel (Unio mancus), were assessed using oxidative stress parameters and histopathology. The environmentally relevant concentration of 5 ?g/l copper pyrithione was applied as a 96 h semi-static exposure. MDA levels in digestive gland (DG) significantly increased, compared to a control group (p < 0.001). Gill MDA levels also increased, but not significantly (p > 0.05). GSH level in DG increased significantly (p < 0.05), and gill tissue levels also increased but not significantly (p > 0.05). Levels of SOD, GPx activities, and AOPP levels did not change significantly (p > 0.05). The most prominent histopathological alterations in the gills were haemocyte infiltration, lipofuscin aggregates and lamellar deformations with tubule degeneration and accumulated lipofuscin aggregates in DG tubules. CuPT impacts antioxidant defense systems even during sublethal exposure of Unio mancus as the freshwater model organism.
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