唑来膦酸对去卵巢小鼠下颌骨骨结构的影响

IF 0.3 4区 医学 Q4 ENGINEERING, BIOMEDICAL Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI:10.2485/jhtb.31.207
Yusuke Oomura, S. Matsunaga, M. Okamura, Taiki Suzuki, N. Kasahara, S. Abe, Takeshi Nomura
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引用次数: 0

摘要

目的:研究唑来膦酸对骨质疏松模型小鼠下颌骨质量的影响。对切除卵巢的小鼠给予唑来膦酸,取下颌骨。制备Pol抛光标本,分析下颌牙槽区和基底区生物磷灰石(BAp)晶体排列和胶原纤维束的变化。发现卵巢切除术增加了BAp晶体排列。卵巢切除术后给予唑来膦酸使下颌骨基底区BAp晶体排列正常化。然而,肺泡区BAp晶体排列明显下降。卵巢切除术降低了肺泡区和基底区胶原纤维束的直径,并显著增加了其长度。卵巢切除术后给予唑来膦酸可减少胶原纤维束的直径和长度。这些结果表明,下颌骨的微结构变化可以补偿骨质疏松引起的骨量损失,并适应咀嚼引起的负载环境。有趣的是,他们认为唑来膦酸以特定部位的方式严重降低骨质疏松性牙槽骨的骨质量。
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Effect of Zoledronic Acid on Bone Structure of the Mandible in Ovariectomized Mice
: The objective of this study was to determine the effect of zoledronic acid on mandibular bone quality in osteo porotic model mice. Zoledronic acid was administered to ovariectomized mice, and mandibular bone was harvested. Pol ished specimens were prepared, and the biological apatite (BAp) crystal alignment and changes in collagen fiber bundles in the alveolar and basal regions of the mandible were analyzed. It was found that ovariectomy increased BAp crystal align -ment. The administration of zoledronic acid post-ovariectomy normalized BAp crystal alignment in the basal region of the mandible. However, BAp crystal alignment in the alveolar region decreased significantly. Ovariectomy decreased the diam eters of collagen fiber bundles in both the alveolar and basal regions and significantly increased their lengths. The adminis tration of zoledronic acid post-ovariectomy decreased both the diameters and lengths of collagen fiber bundles. These re sults showed that the microarchitecture of the mandibular bone changes to compensate for osteoporosis-induced loss of bone mass and adapts to the load environment resulting from mastication. Interestingly, they suggested that zoledronic acid severely reduces the bone quality of osteoporotic alveolar bone in a site-specific manner.
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来源期刊
Journal of Hard Tissue Biology
Journal of Hard Tissue Biology ENGINEERING, BIOMEDICAL-
CiteScore
0.90
自引率
0.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Information not localized
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