The potential impact of the ketogenic diet on gut microbiota in the context of neurological disorders

Abstract One of the most important functional parts of a human intestinal tract is the microscopic intestinal barrier. Its function is to ensure the correct nutrient absorption and to protect against multiple pathogens, xenobiotics, and environmental toxins. Intestinal microbiota is an integral part of the intestinal epithelium. Human microbiota and their host interact with each other, both directly and indirectly, via multiple intermediates and metabolites. Some dietary fat that is not fully digested reaches the distal parts of the intestinal tract, where an interaction with gut microbiota takes place. Studies have shown that an animal-product based diet that provides a greater supply of saturated fat increases the number of bile-resistant microorganisms, including Bilophila. The total amount of Alistipes and Bacteroides is also increased. Long-term consumption of animal-based foods contributes to the formation of the enterotype described as the Bacteroides type. The ketogenic diet is mainly based on animal fats. The changes induced by this higher consumption of animal fats are associated with unfavorable metabolic changes. However, more and more research has shown evidence of the therapeutic properties of a ketogenic diet as far as neurodegenerative and metabolic diseases are concerned. Recent reports suggest that the protective effect of a ketogenic diet is highly dependent on the gut microbiota. This review focuses on the correlation between the influence of ketogenic diet on the intestinal microbiota changes observed while analyzing patients with diseases such as epilepsy, Alzheimer's disease, autism spectrum disorder, and multiple sclerosis.