鞘氨醇-1-磷酸受体亚型1拮抗剂可能是吗啡诱导的痛觉过敏和抗痛觉耐受性的未满足的医学需求

Q4 Medicine Douleur Et Analgesie Pub Date : 2021-01-01 DOI:10.3166/dea-2021-0165
Y. Brik
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引用次数: 0

摘要

阿片类药物,如吗啡,尽管有许多副作用,但经常用于慢性疼痛管理。正在进行的研究旨在寻找新的治疗方法来替代阿片类药物或减少其长期使用造成的严重不良反应:阿片类药物引起的痛觉过敏和抗痛觉耐受性。在最近的一项研究中,Doyle等人(2020)证明中枢神经系统鞘氨醇-1-磷酸受体亚型1 (S1PR1)的激活有助于吗啡诱导的慢性疼痛啮齿动物模型的痛觉过敏和抗疼痛耐受性。通过使用具有功能性拮抗特性的分子(其中一些已被fda批准用于多发性硬化症治疗)靶向S1PR1,在不改变吗啡药代动力学或疗效的情况下,显著降低了痛感和耐受性。
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Sphingosine-1-phosphate Receptor Subtype 1 Antagonists may be the Unmet Medical Need for Morphine-induced Hyperalgesia and Antinociceptive Tolerance
Opioids such as morphine are frequently used for chronic pain management despite their many adverse effects. Ongoing research aims at either finding new treatments to replace opioids or reducing its heavy adverse effects due to long-term use: opioid-induced hyperalgesia and antinociceptive tolerance. In a recent study, Doyle et al. (2020) demonstrate that the activation of sphingosine-1-phosphate receptor subtype 1 (S1PR1) in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in a rodent model of chronic pain. By targeting S1PR1 with molecules with functional antagonistic properties (some of which are FDA-approved for multiple sclerosis treatment), hyperalgesia and tolerance were significantly reduced without modifying morphine pharmacokinetics or efficacy.
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来源期刊
Douleur Et Analgesie
Douleur Et Analgesie 医学-临床神经学
CiteScore
0.30
自引率
0.00%
发文量
17
审稿时长
>12 weeks
期刊介绍: Douleur et Analgésie, première revue internationale francophone consacrée à la douleur, a été créée en 1988. De par la qualité scientifique et l’indépendance de ses publications, ce trimestriel a reçu d’emblée un accueil favorable auprès des chercheurs et cliniciens spécialisés dans le domaine. Á l’occasion de la reprise de la revue en 2006 par les Éditions Springer, le comité éditorial a souhaité s’ouvrir davantage à la francophonie, y compris nord américaine, pour mieux partager les connaissances et renforcer la valeur scientifique de la revue.
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