Complex preparation for pregnancy of women with chronic recurrent cystitis and pelvic congestion syndrome

Aim: to assess the effect of "Pregnoton" food supplement on pelvic venous hemodynamics in women with pelvic congestion syndrome, risk of urogenital infection recurrences during preparing for pregnancy, and sperm motility in the female genital tract. Patients and Methods: the study enrolled 87 women with recurrent cystitis (disease duration 1–5 years) secondary to pelvic congestion syndrome. Sixty-two women received "Pregnoton" to improve pelvic venous tone and prevent detrusor muscle ischemia. Later, pregnancy occurred in 20 women included in the study group. The control group included 25 women with recurrent cystitis secondary to pelvic congestion syndrome who did not receive "Pregnoton". Sperm motility was evaluated by postcoital test. In addition, pain severity, chronic cystitis recurrence rate, and pelvic venous hemodynamics were assessed. Results: women who received "Pregnoton" reported significant pain reduction during the pregnancy (from 6.3 to 3.1 points by pain scale) compared to control group women who reported more severe pain (from 5.8 to 7.8 points). In addition, improvement of pelvic venous hemodynamics (associated with further reduction in inflammation of the lower urinary tract) was detected in the study group. The therapeutic efficacy of preparation for pregnancy in women with recurrent cystitis secondary to pelvic congestion syndrome was 90% in the study group. Exacerbations of chronic cystitis were identified in two women (10%) of the study group and ten women (40%) of the control group. Conclusion: preparation for pregnancy in women with chronic recurrent cystitis and pelvic congestion syndrome using complex "Pregnoton" improves hemodynamics, lab test results, and clinical signs of bladder inflammation and reduces pain severity. KEYWORDS: food supplement, pelvic congestion syndrome, cystitis, preparation for pregnancy, treatment. FOR CITATION: Nashivochnikova N.A., Krupin V.N., Zubova S.Yu., Leanovich V.E. Complex preparation for pregnancy of women with chronic recurrent cystitis and pelvic congestion syndrome. Russian Journal of Woman and Child Health. 2022;5(1):11–17 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-11-17.