锡金喜马拉雅地区民族药用植物的化学成分、抗氧化和抗菌潜力

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI:10.36468/pharmaceutical-sciences.1083
M. Singh, Khashti Dasila, Archana Chettri, R. Jain, A. Dhyani, A. Pandey
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摘要

本文对锡金-喜马拉雅地区的4种重要民族药用植物进行了研究,即:芦笋、紫茎泽兰。,毛癣菌(Haw.)对其进行民族药理学研究,以确定其民族药理学效力。对所选植物甲醇根提取物的总酚含量、总黄酮含量、抗氧化和抗菌活性进行了研究。其中,毛连根甲醇提取物的总酚含量最高(911.4±0.124 mg没食子酸等量/g提取物),在2,2-二苯基-1-吡啶肼和2,2-氮唑(3-乙基苯并噻唑啉-6-磺酸)试验中表现出良好的活性,半最大抑制浓度分别为10µg/ml和1.0µg/ml。毛缕草根甲醇提取物对革兰氏阴性菌大肠杆菌(600µg/ml)和放线菌链霉菌(800µg/ml)的最低抑菌浓度最低,具有较高的抑菌效果。利用高效液相色谱法进一步研究了毛缕草和芦笋根提取物中酚类化合物的含量。毛缕草和芦笋提取物中含有大量的卑尔根素、没食子酸、绿原酸、儿茶素、对香丁酸和间香丁酸。综上所述,本研究为所选植物的生物活性提供了科学依据,并推荐纤毛草和河尾新妇作为药物开发的候选植物
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Phytochemicals, Antioxidant and Antimicrobial Potential of Ethnomedicinal Plants of Sikkim Himalaya
In the present study, four important ethnomedicinal plants of Sikkim Himalaya viz ., Astilbe rivularis Buch-Ham ex. D. Don, Eupatorium adenophorum Spreng., Bergenia ciliata (Haw.) Sternb and Artemisia vulgaris L. were investigated to ensure its ethno pharmacological potency. The methanolic root extracts of the selected plants were investigated for total phenolic content, total flavonoid content, antioxidant and antimicrobial activities. Among the tested extracts, the root methanolic extract of Bergenia ciliata contained the highest total phenolic content (911.4±0.124 mg gallic acid equivalents/g extract) and showed exceptional activity in 2,2-diphenyl-1-picrylhydrazyl and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid assays with half-maximal inhibitory concentration value of 10 µg/ml and 1.0 µg/ml, respectively. The minimum inhibitory concentration of Bergenia ciliata root methanolic extract was also found to be the lowest for gram-negative bacteria Escherichia coli (600 µg/ml) and actinomycetes Streptomyces sp. (800 µg/ml), suggesting high and effective potency against microbes. Bergenia ciliata and Astilbe rivularis root extracts were further investigated for phenolic compounds using high performance liquid chromatography. The extracts of Bergenia ciliata and Astilbe rivularis were found to contain substantial amount of bergenin, gallic acid, chlorogenic acid, catechin, p-coumeric and m-coumeric acid. In conclusion, this study gives scientific evidence on the biological activities of the selected plant species and recommends Bergenia ciliata and Astilbe rivularis as candidate plants for pharmaceutical drug development
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期刊介绍: The Indian Journal of Pharmaceutical Sciences (IJPS) is a bi-monthly Journal, which publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Therapeutics, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacovigilance, Pharmacoepidemiology, Pharmacoeconomics, Drug Information, Patient Counselling, Adverse Drug Reactions Monitoring, Medication Errors, Medication Optimization, Medication Therapy Management, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on current topics in Pharmaceutical Sciences are also considered for publication by the Journal.
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