The Relationship between Oxidative Stress, Obesity and Type 2 Diabetes

In some forms of obesity, the accumulation of fat in “bad places”, that is, somewhere else than in adipocytes, seems to be responsible for diabetes associated with impaired insulin signals. In this case, mild weight loss can sometimes correct diabetes [1]. In turn diabetes, characterized by high blood sugar, can cause severe damage to the body. Oxidative stress in turn is a highly incriminated phenomenon in the pathophysiology of these two diseases. In fact, free radicals are harmful to the body, their frequent accumulation in the cells of obese subjects generally leads to the disruption of the role of insulin and the development of a state of insulin resistance thus preparing for the installation of true non-insulin-dependent diabetes. For this reason, it seems important to take this oxidative stress in obese and diabetic for better treatment. Many epidemiological studies indicate a relationship between obesity and diabetes and to better understand this relationship, we found it necessary to study the links between serum levels of various variables including insulin, vitamin E, and some cations involved in a major metabolic process incriminated in the pathophysiology of these two diseases: oxidative stress (we study magnesium (Mg), zinc (Zn) and calcium (Ca)), in obese diabetic type 2 and obese non diabetics. Patients and Methods