Modern Approach to Prevention of Chronic Recurrent Aphthous Stomatitis

Aim: To analyse and summarize the data of modern scientific literature for the last 10 years on modern approaches to the prevention of chronic recurrent aphthous stomatitis, etiology, pathogenesis and treatment of this disease. Materials and Methods: Analysis and generalization of data from the modern scientific literature on the etiology, pathogenesis, prevention and treatment of CRAS based on databases such as Scopus, Web of Science, MedLine, PubMed, NCBI, the study of which does not exceed 10 years, including literature reviews and results of clinical trials. Conclusions: The prevention of chronic recurrent aphthous stomatitis requires a comprehensive and individualized approach to solve this issue. Reduction of this disease to one cause becomes serious due to its polyetiology, which makes it more difficult to predict the causes of recurrence and solution of the prevention issue. Trigger mechanisms that provoke the formation of CRAS differ in various patients (stress, mechanical disorders, the nature of nutrition, lack of vitamins or trace elements, infections, etc.). However, the immunopathogenetic mechanism may be a common link for the main triggers of the aphthae recurrence emergence. Due to the imperfect understanding of etiopathogenetic factors, the prevention of chronic recurrent aphthous stomatitis is aimed at increasing the intervals between the appearance of new lesions, reducing the number of aphthae and their size, so in other words, it is secondary.