METHOD OF CORRECTING NONSPECIFIC IMMUNITY IN PATIENTS WITH ORAL CANCER

Aim: To evaluate the antioxidant-prooxidant system of oral fluid, indicators of antimicrobial protection and bacterial contamination of the oral cavity in patients with cancer of the oral cavity and oropharynx at the stages of surgical treatment with topical lysozyme in the form of mucosa-adhesive phytogel. Materials and Methods: The study was performed in 38 patients (20 men and 18 women) with stage I-III oral cancer. The average age of patients was 56.5 years (from 33 to 75 years). The normal group included 10 people without changes in the mucous membrane of the oral cavity. Catalase, urease, lysozyme and malonic dialdehyde (MDA) activity were determined. Тhe antioxidant-prooxidant index (API) was calculated and the degree of dysbiosis. The study was performed on day 2 of hospitalization and day 14 of treatment. In the experimental group, the correction of local immunity was performed. Results: The conducted biochemical studies of oral fluid of patients with tumors of the oral cavity demonstrate the high effectiveness of the proposed local treatment. Thus, under its influence in the oral cavity of patients found a decrease in the intensity of lipid peroxidation (MDA content), reduction of microbial contamination (urease activity) and the degree of dysbiosis with a simultaneous increase in nonspecific antimicrobial protection (lysozyme activity) and antioxidant system. Conclusions: Topical application of muco-adhesive phytogel Lysozyme in patients with tumors of the oral cavity in the postoperative period indicate its antimicrobial and antioxidant efficacy, increase local immunity.