Josefa Antonia Rodríguez García, Paula Daniela Morales, N. Molina
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Aislamiento de exosomas a partir de biopsia líquida y su potencial aplicación en la clínica
Exosomes are extracellular micro-vesicles secreted by all cell types that have become of high-priority due to their potential clinical application for identification of new biomarkers for diagnosis, prognosis, and monitoring of neuro degenerative diseases and cancer and also, to determine their potential therapeutic application. Since these vesicles are found naturally in body fluids such as blood, urine, or saliva, it is possible to isolate them from a liquid biopsy to analyze their content, elucidate their interaction with different cell populations (crosstalk), and determine its effect during the development of particular pathologies. In this review we address the latest findings related to the design and application of extracellular vesicle-based therapies, particularly exosomes, for the treatment of cancer or as biomarkers for diagnosis, prognosis, or monitoring of diseases.
期刊介绍：
The Revista Colombiana de Cancerología is an official publication of the Instituto Nacional de Colombia (INC). The Revista is published quarterly with the aim of broadening and disseminating knowledge in the field of oncology. The Revista publishes articles on: molecular carcinogenic mechanisms and treatment responses; cancer epidemiology; clinical features and treatment of neoplastic disease and public health campaigns to control cancer. Manuscripts which contain original material shall be accepted for possible publication. Neither the article nor any part of its contents (including statistical or graphic content) may have been published or submitted for publication in any media other than the Revista Colombiana de Cancerología. No acceptance shall be made of preliminary reports (abstracts or posters) presented at scientific meetings, neither of press releases on programmed meetings. All manuscript copies shall be placed at the disposition of the Journal Editorial Board. Under exceptional circumstances, secondary publications in Spanish or other languages may be submitted, provided they comply with certain conditions which justify said submission.
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