微rna在心血管疾病中的研究进展

中国综合临床 Pub Date : 2020-01-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2020.01.021

Gaoshang Wang, Xuebin Zhan

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引用次数: 0

摘要

目的MicroRNAs (miRNAs)是一种内源性短链rna，长度约为22 NT，具有高度保守性，不具有编码功能。成熟mirna通过特异性结合靶基因的3 '非翻译区，在转录后水平降解基因的mRNA或阻碍其翻译，从而负向调节靶基因的表达，发挥生物学作用。近年来，mirna在心血管疾病中的研究日益深入。大量证据表明，mirna在许多心血管疾病的发病机制中发挥着重要作用，将成为心血管疾病诊断和预后评价的潜在标志物和新的治疗靶点。关键词:MicroRNAs;心血管疾病;生物标记物

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Research progress of microRNAs in cardiovascular diseases

Objective MicroRNAs (miRNAs) are endogenous short stranded RNAs with a length of about 22 NT, which are highly conserved and have no coding function.Mature miRNAs play a role by specifically binding to the 3′untranslated region of the target gene, degrading the mRNA of the gene or hindering its translation at the post transcriptional level, so as to negatively regulate the expression of the target gene and play a biological role.In recent years, the research of miRNAs in cardiovascular diseases is increasingly in-depth.A large number of evidences show that miRNAs play a role in the pathogenesis of many cardiovascular diseases, and will become a potential marker and new treatment target for the diagnosis and prognosis evaluation of cardiovascular diseases. Key words: MicroRNAs; Cardiovascular diseases; Biomarkers

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.