峰鼻毒蛇咬伤致肺出血:甲泼尼松龙治疗效果佳1例报告及文献复习

A. Srirangan, J. Pushpakumara, K. Wanigasuriya
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摘要

背景:驼鼻毒蛇咬伤是斯里兰卡最常见的毒蛇咬伤,发病率高。特定的抗蛇毒是不可用的驼鼻毒蛇中毒,这通常是管理与支持治疗。肺出血是驼鼻毒蛇咬伤的一种不寻常的表现。在这里我们提出一个病例驼鼻毒蛇中毒合并肺出血,并成功地治疗全身类固醇。据我们所知,这在以前的文献中没有报道过。病例介绍:一名先前健康的55岁男子在被人鼻蛇咬伤18小时后被送往当地医院。患者出现双侧严重肺出血,表现为快速去饱和,需要插管和机械通气,气管内管出血,胸部x线片显示双侧肺泡影。他没有其他出血症状。由于病情危及生命,他接受了甲基强的松龙脉冲治疗。随着x线改变的分辨率,缺氧迅速改善。24小时后,他成功地脱离了呼吸机。结论:本病例强调了在没有其他出血表现的情况下,在驼鼻毒蛇咬伤后出现去饱和和肺泡影的患者怀疑肺出血的重要性。早期和及时的全身性类固醇治疗可以挽救这些患者的生命。
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Pulmonary Haemorrhage due to Hump-Nosed Viper Bite: Excellent Response to Methyl Prednisolone-Case Report and Review of Literature
Background: Hump-nosed viper bite, the commonest venomous snake bite in Sri Lanka, is associated with significant morbidity. Specific anti-venom is not available for hump-nosed viper envenomation which is usually managed with supportive treatment. Pulmonary hemorrhage is an unusual manifestation of hump-nosed viper bite. Here we present a case of hump-nosed viper envenomation which complicated by pulmonary hemorrhage and was successfully treated with systemic steroids. To the best of our knowledge, it has not been reported in the literature before. Case Presentation: A previously healthy 55-year-old man presented to the local hospital 18 hours after a humpnosed viper bite. He developed bilateral severe pulmonary hemorrhages, evidenced by rapid desaturation which needed intubation and mechanical ventilation, bleeding from the endotracheal tube and bilateral alveolar shadows in a chest X-ray. He had no other bleeding manifestations. Because of the life-threatening situation, he was treated with methylprednisolone pulse therapy. There was a rapid improvement of hypoxia with a resolution of X-ray changes. He was successfully weaned off from the ventilation after 24 hours. Conclusion: This case highlights the importance of suspecting pulmonary hemorrhage in a patient who develops desaturation and alveolar shadow following hump-nosed viper bite even in the absence of other bleeding manifestation. Early and timely treatment with systemic steroid can be lifesaving in such patients.
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