炎症性肠病microRNA的研究进展

Q4 Medicine 胃肠病学 Pub Date : 2011-01-01 DOI:10.3969/J.ISSN.1008-7125.2011.05.013

Jihua Cheng, L. Xia

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引用次数: 0

摘要

炎症性肠病(IBD)是一种慢性肠道炎症性疾病，其病因尚未明确。近期研究表明，IBD患者血清和肠道组织中microRNA(miRNA)表达频繁改变，miRNA表达异常与疾病活动性、病变部位等相关。miRNA在IBD的诊断、发病机制探索以及靶向治疗中发挥着重要作用。本文综述了miRNA在IBD患者中的异常表达，旨在阐明miRNA在IBD发病发展中的作用，并进一步为其临床应用提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progress in Study of microRNA in Inflammatory Bowel Disease

Inflammatory bowel disease(IBD)is a chronic intestinal inflammatory disease,and its etiology has not yet been clarified.Recent studies have shown that expressions of microRNA(miRNA)were frequently altered in serum and intestinal tissue of patients with IBD,and the aberrant miRNA expressions are correlated with the disease activity and site of lesion,etc.miRNA plays a role in the diagnosis and exploring disease pathogenesis of IBD,as well as its targeted therapy.This article reviewed the aberrant miRNA expressions in patients with IBD in order to clarify the role of miRNA in the pathogenesis and development of IBD,and to further provide the evidence for its clinical application.

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来源期刊

胃肠病学 Medicine-Gastroenterology

CiteScore

0.10

自引率

0.00%

发文量

4567

期刊介绍： Gastroenterology is an academic journal sponsored by Shanghai Jiao Tong University School of Medicine. It mainly publishes original research papers, reviews and comments in this field. The journal was founded in 1996 and is included in well-known databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences) and Statistical Source Journal (China's Excellent Science and Technology Papers Journal). It is one of the national key academic journals under the jurisdiction of the Ministry of Education. Gastroenterology enjoys a high reputation and influence in the academic community. The articles published in this journal have a high academic level and practical value, providing readers with more actual cases and industry information, and have received widespread attention and citations from readers.