Pub Date : 2015-09-25DOI: 10.3969/J.ISSN.1008-7125.2015.09.006
Xiao-Ying Meng, M. Ji, Yi Fang, Jiachuan Wu, Lu Chen, Lu Xia
Background: Inflammatory bowel disease( IBD) is a group of chronic and non-specific intestinal inflammatory diseases of undetermined origin. Functional impairment of macrophages has been associated with the dysregulation of mucosal immunity in intestinal tract of patients with IBD. Aims: To investigate the correlation of serum levels of macrophage polarization-related cytokines with the development and disease activity of IBD. Methods: A total of 105 IBD patients admitted from May 2013 to May 2014 at Shanghai Ruijin Hospital were recruited,of them 65 were Crohn's disease( CD) and 40 were ulcerative colitis( UC). Twenty-four patients with colonic polyps were served as controls. Serum samples were obtained and the levels of interleukin-1beta( IL-1β),IL-6,IL-10,IL-13,interferon-gamma( IFN-γ) and inducible nitric oxide synthase( i NOS) were determined by ELISA method. Results: Serum levels of IL-1β,IL-6,IL-10,IL-13 and IFN-γ were significantly higher in CD group than in control group( P 0. 05),and serum levels of IL-10,IL-13 and IFN-γ were significantly higher in UC group than in control group( P 0. 05). Logistic regression analysis revealed that serum IL-13( OR = 1. 009,P = 0. 005) and i NOS( OR = 0. 982,P = 0. 013) were correlated with CD,while Spearman correlation coefficient demonstrated a link between serum IL-10 and disease activity of CD( rs=- 0. 432,P =0. 014). No correlations were observed between serum levels of these cytokines and development and disease activity of UC( P 0. 05). Conclusions: Serum levels of macrophage polarization-related cytokines increase to varying degrees in IBD patients,but these cytokines have no obvious correlations with IBD and its disease activity. Presumably,theses cytokines are only involved in but not the triggers in the development of IBD.
{"title":"Levels and Significance of Serum Macrophage Polarization-related Cytokines in Patients with Inflammatory Bowel Disease","authors":"Xiao-Ying Meng, M. Ji, Yi Fang, Jiachuan Wu, Lu Chen, Lu Xia","doi":"10.3969/J.ISSN.1008-7125.2015.09.006","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-7125.2015.09.006","url":null,"abstract":"Background: Inflammatory bowel disease( IBD) is a group of chronic and non-specific intestinal inflammatory diseases of undetermined origin. Functional impairment of macrophages has been associated with the dysregulation of mucosal immunity in intestinal tract of patients with IBD. Aims: To investigate the correlation of serum levels of macrophage polarization-related cytokines with the development and disease activity of IBD. Methods: A total of 105 IBD patients admitted from May 2013 to May 2014 at Shanghai Ruijin Hospital were recruited,of them 65 were Crohn's disease( CD) and 40 were ulcerative colitis( UC). Twenty-four patients with colonic polyps were served as controls. Serum samples were obtained and the levels of interleukin-1beta( IL-1β),IL-6,IL-10,IL-13,interferon-gamma( IFN-γ) and inducible nitric oxide synthase( i NOS) were determined by ELISA method. Results: Serum levels of IL-1β,IL-6,IL-10,IL-13 and IFN-γ were significantly higher in CD group than in control group( P 0. 05),and serum levels of IL-10,IL-13 and IFN-γ were significantly higher in UC group than in control group( P 0. 05). Logistic regression analysis revealed that serum IL-13( OR = 1. 009,P = 0. 005) and i NOS( OR = 0. 982,P = 0. 013) were correlated with CD,while Spearman correlation coefficient demonstrated a link between serum IL-10 and disease activity of CD( rs=- 0. 432,P =0. 014). No correlations were observed between serum levels of these cytokines and development and disease activity of UC( P 0. 05). Conclusions: Serum levels of macrophage polarization-related cytokines increase to varying degrees in IBD patients,but these cytokines have no obvious correlations with IBD and its disease activity. Presumably,theses cytokines are only involved in but not the triggers in the development of IBD.","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"20 1","pages":"538-541"},"PeriodicalIF":0.0,"publicationDate":"2015-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.3969/J.ISSN.1008-7125.2013.12.003
Yanjun Feng, Qian Liu, Yi Fang, R. Song, Yiye Wan, Jiansheng Liu, Haiwei Wang, Du Yanzhi, Ji Zhang, Lu Xia
{"title":"Role of epidermal growth factor and its receptor in regulating proliferation of colon cancer stem cells","authors":"Yanjun Feng, Qian Liu, Yi Fang, R. Song, Yiye Wan, Jiansheng Liu, Haiwei Wang, Du Yanzhi, Ji Zhang, Lu Xia","doi":"10.3969/J.ISSN.1008-7125.2013.12.003","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-7125.2013.12.003","url":null,"abstract":"","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"18 1","pages":"714-719"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.3969/J.ISSN.1008-7125.2012.12.008
B. Shen
{"title":"Colonoscopy and histology in the diagnosis of inflammatory bowel disease","authors":"B. Shen","doi":"10.3969/J.ISSN.1008-7125.2012.12.008","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-7125.2012.12.008","url":null,"abstract":"","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"17 1","pages":"736-740"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70179978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-01DOI: 10.3969/J.ISSN.1008-7125.2012.09.003
Li Zhang, Yue Tian, Peng Li, Yong-dong Wu, Shutian Zhang, M. Lin
Background:Estrogen and estrogen receptor(ER) are considered to play important roles in the tumorigenesis and progression of colon cancer,however,the mechanism of ER in colon caner is still unclear.Adaptor protein p66Shc is upregulated by steroid hormones in hormone-sensitive cancer cells,which is correlated with the steroid hormone-stimulated cell proliferation.Aims:To investigate the expressions and significance of ER and p66Shc in colon cancer.Methods: Protein expressions of ER and p66Shc in 65 paraffin-embedded colon cancer tissue and the corresponding adjacent noncancerous tissue were detected by immunohistochemistry.Correlation of p66Shc protein expression with the clinicopathological characteristics of colon cancer was analyzed.Results;Expressions of ER and p66Shc protein were located in nucleus and cytoplasm,respectively.Positivity rates of both ER and p66Shc protein were significantly higher in colon cancer tissue than in adjacent non-cancerous tissue(ER:47.7%vs.0%,P 0.01;p66She:49.2%vs.0%,P 0.01).Moreover,positive correlation was found between ER and p66Shc protein expressions(r = 0.43,P 0.05 ). Expression of p66Shc protein had no correlation with gender,age,primary tumor location,tumor size,gross type,depth of tumor invasion,lymph node metastasis and AJCC stage,however,it was significantly correlated with histological grading of colon cancer(well differentiated;22.2%,moderately differentiated:47.7%,poorly differentiated;75.0%,P = 0.046).Conclusions;Colon cancer might be an estrogen-sensitive malignancy.Estrogen and ER might cooperate with p66Shc to play a role in the tumorigenesis and progression of colon cancer.
背景:雌激素和雌激素受体(Estrogen receptor, ER)被认为在结肠癌的发生发展中起重要作用，但雌激素受体在结肠癌中的作用机制尚不清楚。在激素敏感的癌细胞中，受体蛋白p66Shc被类固醇激素上调，这与类固醇激素刺激的细胞增殖有关。目的:探讨ER和p66Shc在结肠癌中的表达及意义。方法:采用免疫组化方法检测65例石蜡包埋的结肠癌组织及其癌旁非癌组织中ER和p66Shc蛋白的表达。分析了p66Shc蛋白表达与结肠癌临床病理特征的相关性。结果:ER蛋白和p66Shc蛋白分别表达于细胞核和细胞质中。结肠癌组织中ER和p66Shc蛋白的阳性率明显高于癌旁非癌组织(ER:47.7%vs. p66Shc)。0%, P 0.01; p66She: 49.2% vs。0%, P 0.01)。ER与p66Shc蛋白表达呈正相关(r = 0.43,P 0.05)。p66Shc蛋白的表达与性别、年龄、原发肿瘤部位、肿瘤大小、大体类型、肿瘤浸润深度、淋巴结转移及AJCC分期无关，但与结肠癌的组织学分级(高分化22.2%、中分化47.7%、低分化75.0%，P = 0.046)有显著相关性。结论:结肠癌可能是一种雌激素敏感的恶性肿瘤。雌激素和ER可能协同p66Shc参与结肠癌的发生发展。
{"title":"Expressions and significance of estrogen receptor and adaptor protein p66Shc in colon cancer","authors":"Li Zhang, Yue Tian, Peng Li, Yong-dong Wu, Shutian Zhang, M. Lin","doi":"10.3969/J.ISSN.1008-7125.2012.09.003","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-7125.2012.09.003","url":null,"abstract":"Background:Estrogen and estrogen receptor(ER) are considered to play important roles in the tumorigenesis and progression of colon cancer,however,the mechanism of ER in colon caner is still unclear.Adaptor protein p66Shc is upregulated by steroid hormones in hormone-sensitive cancer cells,which is correlated with the steroid hormone-stimulated cell proliferation.Aims:To investigate the expressions and significance of ER and p66Shc in colon cancer.Methods: Protein expressions of ER and p66Shc in 65 paraffin-embedded colon cancer tissue and the corresponding adjacent noncancerous tissue were detected by immunohistochemistry.Correlation of p66Shc protein expression with the clinicopathological characteristics of colon cancer was analyzed.Results;Expressions of ER and p66Shc protein were located in nucleus and cytoplasm,respectively.Positivity rates of both ER and p66Shc protein were significantly higher in colon cancer tissue than in adjacent non-cancerous tissue(ER:47.7%vs.0%,P 0.01;p66She:49.2%vs.0%,P 0.01).Moreover,positive correlation was found between ER and p66Shc protein expressions(r = 0.43,P 0.05 ). Expression of p66Shc protein had no correlation with gender,age,primary tumor location,tumor size,gross type,depth of tumor invasion,lymph node metastasis and AJCC stage,however,it was significantly correlated with histological grading of colon cancer(well differentiated;22.2%,moderately differentiated:47.7%,poorly differentiated;75.0%,P = 0.046).Conclusions;Colon cancer might be an estrogen-sensitive malignancy.Estrogen and ER might cooperate with p66Shc to play a role in the tumorigenesis and progression of colon cancer.","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"17 1","pages":"527-530"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70179901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-01-01DOI: 10.3969/J.ISSN.1008-7125.2011.05.013
Jihua Cheng, L. Xia
Inflammatory bowel disease(IBD)is a chronic intestinal inflammatory disease,and its etiology has not yet been clarified.Recent studies have shown that expressions of microRNA(miRNA)were frequently altered in serum and intestinal tissue of patients with IBD,and the aberrant miRNA expressions are correlated with the disease activity and site of lesion,etc.miRNA plays a role in the diagnosis and exploring disease pathogenesis of IBD,as well as its targeted therapy.This article reviewed the aberrant miRNA expressions in patients with IBD in order to clarify the role of miRNA in the pathogenesis and development of IBD,and to further provide the evidence for its clinical application.
{"title":"Progress in Study of microRNA in Inflammatory Bowel Disease","authors":"Jihua Cheng, L. Xia","doi":"10.3969/J.ISSN.1008-7125.2011.05.013","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-7125.2011.05.013","url":null,"abstract":"Inflammatory bowel disease(IBD)is a chronic intestinal inflammatory disease,and its etiology has not yet been clarified.Recent studies have shown that expressions of microRNA(miRNA)were frequently altered in serum and intestinal tissue of patients with IBD,and the aberrant miRNA expressions are correlated with the disease activity and site of lesion,etc.miRNA plays a role in the diagnosis and exploring disease pathogenesis of IBD,as well as its targeted therapy.This article reviewed the aberrant miRNA expressions in patients with IBD in order to clarify the role of miRNA in the pathogenesis and development of IBD,and to further provide the evidence for its clinical application.","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"16 1","pages":"307-309"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70179770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.3969/J.ISSN.1008-7125.2009.09.009
L. Pan, B. Shen, D. Yang, D. Hu, Jianfei Huang, X. Meng
Background:Leptin may be involved in the formation and development of liver fibrosis.AngiotensinⅡtype 1 receptor(AT1R) antagonist can decrease the synthesis and secretion of leptin in adipose tissue in rats.Aims:To evaluate the effect of valsartan,an AT1R antagonist,on expression of leptin in rats with immunodamaged hepatic fibrosis.Methods: Thirty-six Sprague-Dawley rats were randomly divided into normal control group,model group and valsartan prevention group.In the latter two groups,liver fibrosis model was constructed by intraperitoneal injection with hog serum.Valsartan (30 mg/kg) was intragastrically administered daily after the construction of liver fibrosis in valsartan prevention group.At the 10th week,all the rats were sacrificed.The degree of fibrosis and collagen area were evaluated by HE and Sirius red staining.Expression of leptin was determined by immunohistochemistry staining.Results:As compared with normal control group,the degree of fibrosis(P0.05),collagen area(10.08%±2.01%vs.0.62%±0.31%,P0.01) and expression of liver tissue leptin(5.05±2.91 vs.0.44±0.27,P0.05) were obviously increased in model group.After intervention with valsartan,all the above-mentioned indices significantly ameliorated.Conclusions:Leptin can induce liver fibrosis,and AT1R antagonist valsartan can delay the development of liver fibrosis via the reduction of leptin expression in liver tissue, which may be one of the mechanisms of its anti-fibrosis effect.
{"title":"Effect of valsartan on expression of leptin in rats with liver fibrosis","authors":"L. Pan, B. Shen, D. Yang, D. Hu, Jianfei Huang, X. Meng","doi":"10.3969/J.ISSN.1008-7125.2009.09.009","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-7125.2009.09.009","url":null,"abstract":"Background:Leptin may be involved in the formation and development of liver fibrosis.AngiotensinⅡtype 1 receptor(AT1R) antagonist can decrease the synthesis and secretion of leptin in adipose tissue in rats.Aims:To evaluate the effect of valsartan,an AT1R antagonist,on expression of leptin in rats with immunodamaged hepatic fibrosis.Methods: Thirty-six Sprague-Dawley rats were randomly divided into normal control group,model group and valsartan prevention group.In the latter two groups,liver fibrosis model was constructed by intraperitoneal injection with hog serum.Valsartan (30 mg/kg) was intragastrically administered daily after the construction of liver fibrosis in valsartan prevention group.At the 10th week,all the rats were sacrificed.The degree of fibrosis and collagen area were evaluated by HE and Sirius red staining.Expression of leptin was determined by immunohistochemistry staining.Results:As compared with normal control group,the degree of fibrosis(P0.05),collagen area(10.08%±2.01%vs.0.62%±0.31%,P0.01) and expression of liver tissue leptin(5.05±2.91 vs.0.44±0.27,P0.05) were obviously increased in model group.After intervention with valsartan,all the above-mentioned indices significantly ameliorated.Conclusions:Leptin can induce liver fibrosis,and AT1R antagonist valsartan can delay the development of liver fibrosis via the reduction of leptin expression in liver tissue, which may be one of the mechanisms of its anti-fibrosis effect.","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"14 1","pages":"547-550"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70179879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-09-01DOI: 10.6557/GJTB.199709_14(3).0006
K. Wu, S. Pan, Sheng‐Hsuan Chen, Jean‐Dean Liu, G. Lien, Chun-Chao Chang
Gallstone ileus is an uncommon mechanical bowel obstruction caused by impaction of one or more gallstones in the intestine. The ileum is involved in about 80% of cases. Difficult and delayed diagnosis and old age of the patients account for its high mortality. We herein report one case with gallstone ileus diagnosed by ultrasound preoperatively in which the patient survived after surgery with only a few complications related to the patient's debilitated medical problems. Emphasis is also put upon how to deal with acute abdomen in elderly patients; in addition to traditional roentgenography, ultrasound may afford a tool to detect gallstone ileus.
{"title":"Ultrasonography in the diagnosis of gallstone ileus: Report of a case","authors":"K. Wu, S. Pan, Sheng‐Hsuan Chen, Jean‐Dean Liu, G. Lien, Chun-Chao Chang","doi":"10.6557/GJTB.199709_14(3).0006","DOIUrl":"https://doi.org/10.6557/GJTB.199709_14(3).0006","url":null,"abstract":"Gallstone ileus is an uncommon mechanical bowel obstruction caused by impaction of one or more gallstones in the intestine. The ileum is involved in about 80% of cases. Difficult and delayed diagnosis and old age of the patients account for its high mortality. We herein report one case with gallstone ileus diagnosed by ultrasound preoperatively in which the patient survived after surgery with only a few complications related to the patient's debilitated medical problems. Emphasis is also put upon how to deal with acute abdomen in elderly patients; in addition to traditional roentgenography, ultrasound may afford a tool to detect gallstone ileus.","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"14 1","pages":"264-268"},"PeriodicalIF":0.0,"publicationDate":"1997-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71327871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-09-01DOI: 10.6557/GJTB.199609_13(3).0007
F. Suk, G. Lien, Sheng‐Hsuan Chen, W. Chung, S. Pan, Jean‐Dean Liu, Chun-Chao Chang, K. Wu, Chi-Tan Hu
Hookworms usually reside in the small intestine, so they are rarely discovered during routine upper gastrointestinal endoscopy (UGIE). We herein report two cases of hookworm infestation diagnosed by UGIE. One of the two cases combined with gastric adenocarcinoma and no parasite ova was detected in stool examination. Ancylostoma duodenale and Necator americanus can infect humans. In Taiwan, N. americanus is prevalent in the north and the east, and A. duodenale is prevalent in the south and the central region. The infection rate in Taiwan is less than 1%. The adult hookworm resides mainly in the jejunum and may be refluxed toward the duodenum and the stomach during bowel contraction. Endoscopically, hookworms are shining red in color, about 10mm in length, and a couple of female and male worms usually hug together tightly. There is no report to suggest the relation between hookworm infestation and gastric malignancy in the literature.
{"title":"Endoscopic diagnosis of hookworm disease: Report of two cases","authors":"F. Suk, G. Lien, Sheng‐Hsuan Chen, W. Chung, S. Pan, Jean‐Dean Liu, Chun-Chao Chang, K. Wu, Chi-Tan Hu","doi":"10.6557/GJTB.199609_13(3).0007","DOIUrl":"https://doi.org/10.6557/GJTB.199609_13(3).0007","url":null,"abstract":"Hookworms usually reside in the small intestine, so they are rarely discovered during routine upper gastrointestinal endoscopy (UGIE). We herein report two cases of hookworm infestation diagnosed by UGIE. One of the two cases combined with gastric adenocarcinoma and no parasite ova was detected in stool examination. Ancylostoma duodenale and Necator americanus can infect humans. In Taiwan, N. americanus is prevalent in the north and the east, and A. duodenale is prevalent in the south and the central region. The infection rate in Taiwan is less than 1%. The adult hookworm resides mainly in the jejunum and may be refluxed toward the duodenum and the stomach during bowel contraction. Endoscopically, hookworms are shining red in color, about 10mm in length, and a couple of female and male worms usually hug together tightly. There is no report to suggest the relation between hookworm infestation and gastric malignancy in the literature.","PeriodicalId":10003,"journal":{"name":"Chinese Journal of Gastroenterology","volume":"13 1","pages":"267-272"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71327993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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