筛选结果表明,金丝桃和金丝桃乙醇提取物对不同的癌细胞具有较强的细胞毒活性

IF 1.1 Q4 BIOPHYSICS AIMS Biophysics Pub Date : 2022-01-01 DOI:10.3934/biophy.2023002
M. Ginovyan, S. Hovhannisyan, Hayarpi Javrushyan, Gohar Sevoyan, Z. Karabekian, N. Zakaryan, N. Sahakyan, N. Avtandilyan
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引用次数: 1

摘要

植物源化合物被认为是开发预防和治疗癌症药物的有前途的替代方法。作为新的抗癌化合物的来源,草药物种的多样性仍然需要仔细的探索。该研究的目的是筛选亚美尼亚民间医学中传统使用的不同草药提取物对某些癌细胞系的细胞毒性作用,并在其中寻找有前景的植物物种。采用MTT法评价植物乙醇提取物对人宫颈癌细胞HeLa和人肺腺癌细胞A549的毒性。用DPPH自由基清除法测定其抗氧化性能。10种草药提取物中有5种对HeLa细胞表现出显著的生长抑制活性。此外,炼金草和金丝桃提取物对人肺腺癌细胞也表现出较强的细胞毒性。这两种植物也具有较高的抗自由基活性。它们的DPPH化学计量值分别为0.4234和0.14437,即1µg植物提取物使DPPH的减少量等于各自的化学计量值(µg)。因此,石竹和石竹提取物是一种有效的细胞毒性和抗氧化剂,具有良好的抗癌潜力。进一步评价它们的体内抗癌特性具有重要意义。
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Screening revealed the strong cytotoxic activity of Alchemilla smirnovii and Hypericum alpestre ethanol extracts on different cancer cell lines
Compounds of plant origin are considered promising alternative approaches in the development of medicines for the prevention and treatment of cancer. The large diversity of herbal species still requires careful exploration as a source for new anticancer compounds. The goal of the study was to screen different herbal extracts traditionally used in Armenian folk medicine for their cytotoxic effect against some cancer cell lines, and to find the prospective plant species among them. The cytotoxicity of the plant ethanol extracts was evaluated with MTT test against HeLa (human cervical carcinoma) and A549 (human lung adenocarcinoma) cells. Antioxidant properties were assessed with DPPH free radical scavenging assay. Five of the tested ten herbal extracts exhibited significant growth-inhibiting activity on HeLa cells. Moreover, Alchemilla smirnovii and Hypericum alpestre extracts also showed potent cytotoxicity on human lung adenocarcinoma cells. These two plants possessed high antiradical activity as well. Their DPPH stoichiometric values were 0.4234 and 0.14437 respectively, meaning that 1 µg of plant extract brought the reduction of DPPH equal to the respective stoichiometric values in µg. Thus, A. smirnovii and H. alpestre extracts expressed themselves as potent cytotoxic and antioxidant agents and could have promising anticancer potential. Further evaluation of their in vivo anticancer properties has much interest.
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来源期刊
AIMS Biophysics
AIMS Biophysics BIOPHYSICS-
CiteScore
2.40
自引率
20.00%
发文量
16
审稿时长
8 weeks
期刊介绍: AIMS Biophysics is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers in the field of biophysics. We publish the following article types: original research articles, reviews, editorials, letters, and conference reports. AIMS Biophysics welcomes, but not limited to, the papers from the following topics: · Structural biology · Biophysical technology · Bioenergetics · Membrane biophysics · Cellular Biophysics · Electrophysiology · Neuro-Biophysics · Biomechanics · Systems biology
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