J. Macri, S. S. Silva, M. M. Miranda, N. Y. Kawakami, T. H. Hayashida, T. Madeira, S. Nixdorf, Vinicius Ricardo Acquaro Junior, S. Ambrósio, W. Verri, R. Cecchini, I. Conchon-Costa, N. S. Arakawa, W. Pavanelli
{"title":"kaurenic Acid对BALB/c巨噬细胞的免疫调节和抗氧化作用","authors":"J. Macri, S. S. Silva, M. M. Miranda, N. Y. Kawakami, T. H. Hayashida, T. Madeira, S. Nixdorf, Vinicius Ricardo Acquaro Junior, S. Ambrósio, W. Verri, R. Cecchini, I. Conchon-Costa, N. S. Arakawa, W. Pavanelli","doi":"10.3844/AJISP.2014.183.188","DOIUrl":null,"url":null,"abstract":"Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFI±, IL-1I² and IFN-I³ while also increased the levels of IL-10. There was also reduction of NO production and induction of anti-oxidant profile. Therefore, in addition to inhibiting inflammation, kaurenoic acid presents immunomodulatory effects per se.","PeriodicalId":88361,"journal":{"name":"American journal of immunology","volume":"10 1","pages":"183-188"},"PeriodicalIF":0.0000,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3844/AJISP.2014.183.188","citationCount":"5","resultStr":"{\"title\":\"Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro\",\"authors\":\"J. Macri, S. S. Silva, M. M. Miranda, N. Y. Kawakami, T. H. Hayashida, T. Madeira, S. Nixdorf, Vinicius Ricardo Acquaro Junior, S. Ambrósio, W. Verri, R. Cecchini, I. Conchon-Costa, N. S. Arakawa, W. Pavanelli\",\"doi\":\"10.3844/AJISP.2014.183.188\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFI±, IL-1I² and IFN-I³ while also increased the levels of IL-10. There was also reduction of NO production and induction of anti-oxidant profile. Therefore, in addition to inhibiting inflammation, kaurenoic acid presents immunomodulatory effects per se.\",\"PeriodicalId\":88361,\"journal\":{\"name\":\"American journal of immunology\",\"volume\":\"10 1\",\"pages\":\"183-188\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3844/AJISP.2014.183.188\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3844/AJISP.2014.183.188\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3844/AJISP.2014.183.188","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro
Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFI±, IL-1I² and IFN-I³ while also increased the levels of IL-10. There was also reduction of NO production and induction of anti-oxidant profile. Therefore, in addition to inhibiting inflammation, kaurenoic acid presents immunomodulatory effects per se.
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