Maternal Demographic and Placental Risk Factors in Term Low Birth Weight in Ghana

Background: Several studies report on factors that associate preterm birth and intrauterine growth restriction with low birth weight (LBW). However, few studies discuss risk factors that associate with LBW for full-term births. No such studies exist that involve a population from Ghana. Method: We used a nested case-control study approach to examine maternal socio-demographic and placental factors that contribute significantly to term LBW in Ghana. We assessed also the incidence of LBW in general at a major teaching hospital facility in Ghana. Results: Univariate and multivariate logistic regression analysis were used to investigate maternal sociodemographic and placental factors that associate with LBW. Following the preliminary univariate analysis, a stepwise logistic regression analysis showed that unstable income source, single motherhood, combined effect of pre-eclampsia and anaemia; ORs of 5.366 (95% CI: 1.986 to 14.497), 21.390 (95% CI: 3.610 to 126.734) and 3.246 (95% CI: 1.074 to 9.814), respectively, and placental weight and irregular insertion of the umbilical cord (variables scaled by a factor of 10-2 to aid interpretation) ORs 0.28 (95% CI: 0.115 to 0.683), 0.010 (95% CI: 0.001 to 0.173 respectively) on the chorionic plate, were risk factors for LBW. The socio-demographic and placental factors reveal a core role of maternal and infant nutritional deficiencies in term LBW in Ghana. The general prevalence of LBW in the Hospital facility was 6.2%. Conclusion: We conclude that poor maternal and infant nutrient supply is key factors in term LBW in Ghana. These factors are amenable to appropriate nutritional and educational interventions.