Bartosz Osuch, Teresa Kucharska, N. Chmielewska, P. Maciejak, J. Szyndler, A. Płażnik
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The role of mitophagy in selected neurodegenerative diseases
Purpose: Mitophagy is a type of selective autophagy, associated with degradation of inefficient mitochondria. The modulation of mitophagy seems to be one of the most important solutions for key factors in the maintenance of neuronal cell homeostasis. This paper overviews the role of mitochondria and mitophagy in the etiology of the most common age-related neurodegenerative diseases, i.e. Alzheimer’s disease (AD) and Parkinson’s disease (PD). Views: In recent years, the role of mitophagy in neurodegenerative diseases has been given more attention. It has been shown that disturbed mitophagy and mitochondrial dysfunction in neurons may contribute to the cell death. In AD and PD, a number of abnormalities related to the expression and function of proteins involved in the process have been revealed. Because mitochondrial dysfunction plays a role in the origin/etiology of those diseases, possible therapeutic strategies aiming to improve quality control systems of mitochondria are also presented. Nowadays, these are mainly strategies improving the energy efficiency and facilitating induction of mitophagy. Conclusions: Recent reports suggest that abnormal function of proteins involved in mitophagy may be an important etiological factor in neurodegenerative diseases. Furthermore, these findings may become the basis for the development of more effective thera pies preventing or alleviating the disease symptoms.
期刊介绍:
The quarterly Advances in Psychiatry and Neurology is aimed at psychiatrists, neurologists as well as scientists working in related areas of basic and clinical research, psychology, social sciences and humanities. The journal publishes original papers, review articles, case reports, and - at the initiative of the Editorial Board – reflections or experiences on currently vivid theoretical and practical questions or controversies. Articles submitted to the journal are evaluated first by the Section Editors, specialists in the fields of psychiatry, clinical psychology, science of the brain and mind and neurology, and reviewed by acknowledged authorities in the respective field. Authors and reviewers remain anonymous to each other.