{"title":"两种典型苋菜科异碳苯乙烯类生物碱及其衍生物的构效关系","authors":"Yubin Ji, Yan Dong, N. Chen, D. Song, Jia Zheng","doi":"10.4028/www.scientific.net/AMM.411-414.3158","DOIUrl":null,"url":null,"abstract":"This paper reviews the structure-activity relationship of two typical Amaryllidaceae isocarbostyril alkaloids, narciclasine, pancratistatin and their derivatives. Varieties structures have important impacts on biological activity of Amaryllidaceae isocarbostyril alkaloids, for example, the nuclear structure of isocarbostyril, the stereochemistry of the B/C ring junction, the C7-hydroxy of ring A, hydroxies of ring C and so on. This study is conducive to find other active groups, conduct structural modifications and provide the rational basis for designing drugs molecular.","PeriodicalId":12383,"journal":{"name":"食品与药品","volume":"411-414 1","pages":"3158 - 3161"},"PeriodicalIF":0.0000,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4028/www.scientific.net/AMM.411-414.3158","citationCount":"0","resultStr":"{\"title\":\"Structure-Activity Relationship of Two Typical Amaryllidaceae Isocarbostyril Alkaloids and their Derivatives\",\"authors\":\"Yubin Ji, Yan Dong, N. Chen, D. Song, Jia Zheng\",\"doi\":\"10.4028/www.scientific.net/AMM.411-414.3158\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This paper reviews the structure-activity relationship of two typical Amaryllidaceae isocarbostyril alkaloids, narciclasine, pancratistatin and their derivatives. Varieties structures have important impacts on biological activity of Amaryllidaceae isocarbostyril alkaloids, for example, the nuclear structure of isocarbostyril, the stereochemistry of the B/C ring junction, the C7-hydroxy of ring A, hydroxies of ring C and so on. This study is conducive to find other active groups, conduct structural modifications and provide the rational basis for designing drugs molecular.\",\"PeriodicalId\":12383,\"journal\":{\"name\":\"食品与药品\",\"volume\":\"411-414 1\",\"pages\":\"3158 - 3161\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4028/www.scientific.net/AMM.411-414.3158\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"食品与药品\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://doi.org/10.4028/www.scientific.net/AMM.411-414.3158\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"食品与药品","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.4028/www.scientific.net/AMM.411-414.3158","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Structure-Activity Relationship of Two Typical Amaryllidaceae Isocarbostyril Alkaloids and their Derivatives
This paper reviews the structure-activity relationship of two typical Amaryllidaceae isocarbostyril alkaloids, narciclasine, pancratistatin and their derivatives. Varieties structures have important impacts on biological activity of Amaryllidaceae isocarbostyril alkaloids, for example, the nuclear structure of isocarbostyril, the stereochemistry of the B/C ring junction, the C7-hydroxy of ring A, hydroxies of ring C and so on. This study is conducive to find other active groups, conduct structural modifications and provide the rational basis for designing drugs molecular.
期刊介绍：
"Food and Drug" (bimonthly) is a scientific journal in the field of food and drug approved by the State Administration of Press, Publication, Radio, Film and Television, with an international standard serial number (ISSN 1672-979X) and a domestic unified serial number (CN 37-1438/R). It is published domestically and internationally. The magazine was founded in 1998 and is managed by Shandong Commercial Group Co., Ltd., sponsored by Shandong Academy of Pharmaceutical Sciences, and co-organized by the Industrial Biochemistry and Molecular Biology Branch of the Chinese Society of Biochemistry and Molecular Biology, Shandong Freda Pharmaceutical Group Co., Ltd., Shandong Biopharmaceutical Association, and Shandong Health Products Industry Association. The main contents include various pharmaceutical disciplines, such as pharmaceutics, pharmacology, medicinal chemistry, drug analysis, traditional Chinese medicine, biopharmaceuticals, clinical pharmacy, pharmaceutical management, etc., as well as academic papers in the field of food, including research and development of health foods, food inspection, food additives, food supervision, etc.
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