姜黄素在衰老过程中改善红细胞的氧化应激

Akshay Kumar, P. Maurya
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引用次数: 0

摘要

一种必需的膳食类黄酮被称为姜黄素,具有积极的健康作用,并抑制活性氧(ROS)的合成。本研究的目的是观察姜黄素治疗后红细胞氧化应激的迹象与年龄的关系。共有116名年龄在20岁至81岁之间的健康志愿者为调查提供了临床相关的血液样本。受试者分为三组:年轻组(20 - 35岁)、中年组(36 - 60岁)和老年组(60 - 60岁)。用10 -5 M叔丁基过氧化氢(t -BHP)体外培养红细胞诱导氧化应激。通过将红细胞与姜黄素(10 -8 M至10 -5 M终浓度)和t -BHP共孵育,检测丙二醛和还原性谷胱甘肽,以评估姜黄素的影响。经t -BHP孵育后,MDA水平显著高于对照组(P <0.001), GSH水平显著低于对照组(P <0.001)。姜黄素通过提高GSH和降低MDA水平,显著(P <0.01)减轻了各年龄组红细胞氧化应激的有害影响。这项研究的结果显示了姜黄素在衰老过程中的潜在作用,它将有助于快速筛选可能保护红细胞免受氧化应激的新化合物。
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Curcumin ameliorates oxidative stress in red blood cells during ageing
An essential dietary flavonoid known as curcumin has positive health effects and inhibits the synthesis of reactive oxygen species (ROS). The aim of this study is to look at signs of oxidative stress in red blood cells (RBCs) treated with curcumin as a function of age. A total of 116 healthy volunteers ranging in age from 20 to 81 years provided clinically pertinent blood samples for the investigation. Three groups of subjects were created: young (20 to 35 years), middle (36 to 60 years), and old (>60 years). Oxidative stress was induced in vitro by incubating RBCs with 10 -5 M tert -butyl hydroperoxide ( t -BHP). Malondialdehyde and reduced glutathione were detected by co-incubating RBCs with curcumin (10 -8 M to 10 -5 M final concentration) and t -BHP to assess the effect of curcumin. After being incubated with t -BHP, the results revealed higher MDA levels ( P <0.001) in comparison to their respective controls and the GSH level significantly ( P <0.001) decreased during ageing. By raising GSH and lowering MDA levels, curcumin treatment in vitro considerably ( P <0.01) mitigated the harmful effect of oxidative stress in RBCs from all age groups. The results of this study showed the potential role of curcumin in the ageing process and it will facilitate the quick screening of novel chemical compounds that may protect RBCs from oxidative stress.
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来源期刊
CiteScore
1.00
自引率
12.50%
发文量
1
审稿时长
52 weeks
期刊介绍: Indian Journal of Natural Products and Resources (IJNPR), a quarterly journal, is dedicated to the exploration of topics that confront both educators, frontline workers in the fields, entrepreneurs and ultimate users of the value added products and their resources pertaining to both plants and animals. It publishes original research papers, reviews and short communications. The scope of the journal is multidisciplinary especially of applied nature. Papers on plant cultivation, fishery, apiary, poultry, dairy, disease and pest control measures, postharvest technology/practices, value added products and utilization of plants and animals in broader sense (including ethnobotany and pharmacology) are considered for publication.
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