Muhammad Afzal Muhammad Afzal, Ejaz Ahmed Ejaz Ahmed, Ahsan Sharif Ahsan Sharif
{"title":"百合花胆碱酯酶抑制萜类化合物","authors":"Muhammad Afzal Muhammad Afzal, Ejaz Ahmed Ejaz Ahmed, Ahsan Sharif Ahsan Sharif","doi":"10.52568/001194/jcsp/45.01.2023","DOIUrl":null,"url":null,"abstract":"Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT-IR, 1Dandamp; 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer’s disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3and#177; 0.02, AChE and 19.0and#177;0.03, BChE while galanthamine as a positive control (0.5 and#177; 0.05, AChE and 8.5and#177;0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cholinesterase Inhibiting Terpenoid from Albizia kalkora\",\"authors\":\"Muhammad Afzal Muhammad Afzal, Ejaz Ahmed Ejaz Ahmed, Ahsan Sharif Ahsan Sharif\",\"doi\":\"10.52568/001194/jcsp/45.01.2023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT-IR, 1Dandamp; 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer’s disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3and#177; 0.02, AChE and 19.0and#177;0.03, BChE while galanthamine as a positive control (0.5 and#177; 0.05, AChE and 8.5and#177;0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.\",\"PeriodicalId\":17253,\"journal\":{\"name\":\"Journal of the chemical society of pakistan\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the chemical society of pakistan\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.52568/001194/jcsp/45.01.2023\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the chemical society of pakistan","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.52568/001194/jcsp/45.01.2023","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Cholinesterase Inhibiting Terpenoid from Albizia kalkora
Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT-IR, 1Dandamp; 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer’s disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3and#177; 0.02, AChE and 19.0and#177;0.03, BChE while galanthamine as a positive control (0.5 and#177; 0.05, AChE and 8.5and#177;0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.
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This journal covers different research areas in the field of Chemistry. These include; Analytical Chemistry, Applied Chemistry, Biochemistry, Environmental Chemistry, Industrial Chemistry, Inorganic Chemistry, Organic Chemistry and Physical Chemistry. The journal publishes full length articles and Reviews from researchers in academia in addition to featuring comments. Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry.
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