血清白细胞介素-36和白细胞介素-38失衡与寻常型银屑病代谢综合征有关

IF 0.3 Q4 DERMATOLOGY Journal of the Egyptian Women's Dermatologic Society Pub Date : 2023-09-01 DOI:10.4103/jewd.jewd_14_23

Marwa Amer, D. Mahgoub, D. Kadry, Ghada Ahmed, Laila A. Rashed, Basma Gaballah, Marwa Kamel

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BMI, waist circumference, arterial blood pressure, fasting blood glucose, and lipid profile were measured. Blood samples were withdrawn, and serum IL-36 and IL-38 levels were measured using enzyme-linked immunosorbent assay. Results Serum IL-36 levels were significantly higher in group A (mean±SD=187.84±32.84 pg/ml) compared with group B (mean±SD=156.5±24.09 pg/ml) (P<0.001), or group C (mean±SD=115.18±14.69 pg/ml) (P<0.001) or group D (mean±SD=38.06±10.18 pg/ml) (P<0.001). Serum IL-38 levels were significantly lower in group A (mean±SD 57.34±19.91 pg/ml) compared with group B (mean±SD=73.9±16.13 pg/ml) (P<0.006) or group C (mean±SD=74.67±12.89 pg/ml) (P=0.002), or group D (mean±SD=212.36±17.55 pg/ml) (P<0.001). In group A, IL-36 had a 75% sensitivity and 70% specificity with a cutoff value of 166.2, whereas IL-38 had an 80% sensitivity and 65% specificity with a cutoff value of 74. There was a significant negative correlation between IL36 and IL-38 levels (r=−0.637, P<0.001). 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引用次数: 0

摘要

背景在银屑病中，白细胞介素(IL)-36被认为是致病驱动因素，而IL-38则下调。对它们在牛皮癣代谢综合征(Ms)中的作用知之甚少。目的探讨寻常型银屑病患者血清IL-36、IL-38与Ms的关系。患者与方法本研究为病例对照研究。80名参与者被分为四组:A组包括20名Ms银屑病患者，B组包括20名非Ms银屑病患者，C组包括20名Ms对照，D组包括20名健康对照。所有参与者都签署了书面知情同意书。进行临床检查和银屑病面积及严重程度指数(PASI)评价。测量BMI、腰围、动脉血压、空腹血糖和血脂。抽取血样，采用酶联免疫吸附法测定血清IL-36和IL-38水平。结果A组血清IL-36水平(平均±SD=187.84±32.84 pg/ml)明显高于B组(平均±SD=156.5±24.09 pg/ml) (P<0.001)、C组(平均±SD=115.18±14.69 pg/ml) (P<0.001)、D组(平均±SD=38.06±10.18 pg/ml) (P<0.001)。A组血清IL-38水平(平均±SD 57.34±19.91 pg/ml)明显低于B组(平均±SD=73.9±16.13 pg/ml) (P<0.006)、C组(平均±SD=74.67±12.89 pg/ml) (P=0.002)、D组(平均±SD=212.36±17.55 pg/ml) (P<0.001)。A组IL-36敏感性75%，特异性70%，临界值为166.2;IL-38敏感性80%，特异性65%，临界值为74。il - 36与IL-38水平呈显著负相关(r= - 0.637, P<0.001)。结论银屑病合并Ms患者IL-36明显升高，IL-38明显降低。IL-36和IL-38之间的失衡可能与牛皮癣中潜在的代谢紊乱有关。

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Imbalance between serum interleukin-36 and interleukin-38 is associated with metabolic syndrome in psoriasis vulgaris

Background In psoriasis, interleukin (IL)-36 is considered a pathogenic driver, whereas IL-38 was downregulated. Little is known about their role in metabolic syndrome (Ms) in psoriasis. Objective To evaluate a possible relation between serum IL-36 and IL-38 and Ms in psoriasis vulgaris. Patients and methods This study was designed as a case–control study. It included 80 participants, who were divided into four groups: group A included 20 psoriasis patients with Ms, group B included 20 psoriasis patients without Ms, group C included 20 controls with Ms, and group D included 20 healthy controls. Written informed consents were signed by all participants. Clinical examination and psoriasis area and severity index (PASI) evaluation were done. BMI, waist circumference, arterial blood pressure, fasting blood glucose, and lipid profile were measured. Blood samples were withdrawn, and serum IL-36 and IL-38 levels were measured using enzyme-linked immunosorbent assay. Results Serum IL-36 levels were significantly higher in group A (mean±SD=187.84±32.84 pg/ml) compared with group B (mean±SD=156.5±24.09 pg/ml) (P<0.001), or group C (mean±SD=115.18±14.69 pg/ml) (P<0.001) or group D (mean±SD=38.06±10.18 pg/ml) (P<0.001). Serum IL-38 levels were significantly lower in group A (mean±SD 57.34±19.91 pg/ml) compared with group B (mean±SD=73.9±16.13 pg/ml) (P<0.006) or group C (mean±SD=74.67±12.89 pg/ml) (P=0.002), or group D (mean±SD=212.36±17.55 pg/ml) (P<0.001). In group A, IL-36 had a 75% sensitivity and 70% specificity with a cutoff value of 166.2, whereas IL-38 had an 80% sensitivity and 65% specificity with a cutoff value of 74. There was a significant negative correlation between IL36 and IL-38 levels (r=−0.637, P<0.001). Conclusion Patients with psoriasis with Ms had significantly higher IL-36 and lower IL-38. Imbalance between IL-36 and IL-38 may be associated with underlying metabolic disturbance seen in psoriasis.

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来源期刊

Journal of the Egyptian Women's Dermatologic Society Medicine-Dermatology

CiteScore

0.50

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： The Journal of The Egyptian Women''s Dermatologic Society (JEWDS) was founded by Professor Zenab M.G. El-Gothamy. JEWDS is published three times per year in January, May and September. Original articles, case reports, correspondence and review articles submitted for publication must be original and must not have been published previously or considered for publication elsewhere. Their subject should pertain to dermatology or a related scientific and technical subject within the field of dermatology.