Diah Puspitosari, A. D. Anjani, K. Ruchiatan, O. Suwarsa, H. Dharmadji, E. Sutedja, S. P. Gondokaryono, Trustia Rizqandaru, R. Hindritiani
The application of sunscreen has been shown to prevent the detrimental effects of ultraviolet. The effectiveness of a sunscreen formulation protection against ultraviolet B is measured by sun protection factor (SPF) and its value determined by in vivo testing is still the gold standard. The consistency between the in vivo and in vitro SPF values is still interesting to investigate, including the influencing factors. To analyze the correlation between the products’ manufacturer estimation in vitro SPF value with the in vivo SPF value and assessing determinant factors that may influence the in vivo SPF value. Ten sunscreen products from various manufacturers were tested in vivo using The European Cosmetic Toiletry and Perfumery Association (COLIPA) method. All the tested products in this study have the manufacturer’s estimated SPF value determined based on in vitro test conducted by the manufacturer. The Spearman correlation test was used for data analysis. All sunscreen products had the estimated SPF values of 30 and 50, for five products each. Nine products were in cream formulations and one in lotion formulation, as ‘day cream’ and ‘BB cream,’ respectively. Six sunscreen products had lower in vivo SPF values compared with the manufacturer’s SPF value estimation, whereas four products had shown higher values. Although statistical analysis showed P value of 0.63 that indicates no significant correlation between both of the SPF values. Several products with the appropriate and higher in vivo SPF values contain octocrylene as a photostabilizer and additional coating materials such as stearic acid, aluminum hydroxide, and alumina. This study demonstrated that the appropriateness of the in vivo SPF value to in vitro-estimated SPF value may be influenced by the photostabilizer substance and combination with additional coating materials also can increase stability and efficacy of the products.
{"title":"Types of ultraviolet filters and their combination used in sunscreen determine the appropriate sun protection factor values in vivo","authors":"Diah Puspitosari, A. D. Anjani, K. Ruchiatan, O. Suwarsa, H. Dharmadji, E. Sutedja, S. P. Gondokaryono, Trustia Rizqandaru, R. Hindritiani","doi":"10.4103/jewd.jewd_90_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_90_23","url":null,"abstract":"\u0000 \u0000 The application of sunscreen has been shown to prevent the detrimental effects of ultraviolet. The effectiveness of a sunscreen formulation protection against ultraviolet B is measured by sun protection factor (SPF) and its value determined by in vivo testing is still the gold standard. The consistency between the in vivo and in vitro SPF values is still interesting to investigate, including the influencing factors.\u0000 \u0000 \u0000 \u0000 To analyze the correlation between the products’ manufacturer estimation in vitro SPF value with the in vivo SPF value and assessing determinant factors that may influence the in vivo SPF value.\u0000 \u0000 \u0000 \u0000 Ten sunscreen products from various manufacturers were tested in vivo using The European Cosmetic Toiletry and Perfumery Association (COLIPA) method. All the tested products in this study have the manufacturer’s estimated SPF value determined based on in vitro test conducted by the manufacturer. The Spearman correlation test was used for data analysis.\u0000 \u0000 \u0000 \u0000 All sunscreen products had the estimated SPF values of 30 and 50, for five products each. Nine products were in cream formulations and one in lotion formulation, as ‘day cream’ and ‘BB cream,’ respectively. Six sunscreen products had lower in vivo SPF values compared with the manufacturer’s SPF value estimation, whereas four products had shown higher values. Although statistical analysis showed P value of 0.63 that indicates no significant correlation between both of the SPF values. Several products with the appropriate and higher in vivo SPF values contain octocrylene as a photostabilizer and additional coating materials such as stearic acid, aluminum hydroxide, and alumina.\u0000 \u0000 \u0000 \u0000 This study demonstrated that the appropriateness of the in vivo SPF value to in vitro-estimated SPF value may be influenced by the photostabilizer substance and combination with additional coating materials also can increase stability and efficacy of the products.\u0000","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141056658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eman M. K. Sanad, Rana R. Sanad, Amany K Shahat, Ahmed M. Hamed
Warts are common dermatological conditions caused by human papilloma virus. Most treatments for human papilloma virus rely on the destruction of involved tissue. The role of vitamin D injection in treating warts is thought to be via regulating cell proliferation and differentiation through the upregulation of vitamin D receptors and the induction of antimicrobial peptides. To assess the clinical efficacy and safety of intralesional vitamin D in the treatment of cutaneous warts and also the significance of peripheral blood toll-like receptors 2 (TLR2) expression and serum levels of 25-hydroxyvitamin D in predicting the therapeutic success. In this prospective interventional study, 50 patients of cutaneous warts were subjected to history taking, proper dermatological examination, and peripheral venous blood collection for detection of TLR2 mRNA expression and a serum level of 25 (OH) D. Vitamin D3 was slowly injected into the base of the largest or the oldest wart at 2-week intervals. A total of 34 (69.4%) patients showed response to intralesional Vitamin D [21 (42.9%) showed complete resolution of all lesions, 13 (26.5%) showed partial clearing] and 15 (30.6%) patients showed poor or no response after four sessions. Serum level of vitamin D did not show a significant relation with treatment response. TLR2 expression was higher in the group showing complete response. Intralesional vitamin D injection offers a safe and cost-effective therapy for different types of cutaneous warts. TLR2 expression in patients’ serum can be used to predict response to treatment by intralesional vitamin D, with better response in patients with higher expression.
疣是由人类乳头瘤病毒引起的常见皮肤病。人类乳头瘤病毒的大多数治疗方法都依赖于破坏受累组织。注射维生素 D 对治疗尖锐湿疣的作用被认为是通过上调维生素 D 受体和诱导抗菌肽来调节细胞的增殖和分化。 为了评估鞘内注射维生素 D 治疗皮肤疣的临床疗效和安全性，以及外周血收费样受体 2（TLR2）表达和血清中 25- 羟维生素 D 水平对预测治疗成功的意义。 在这项前瞻性干预研究中，50 名皮肤疣患者接受了病史采集、适当的皮肤科检查和外周静脉采血，以检测 TLR2 mRNA 表达和血清 25 (OH) D 水平。 共有 34 名（69.4%）患者对局部注射维生素 D 有反应（21 名（42.9%）患者的所有病灶完全消退，13 名（26.5%）患者的部分病灶消退），15 名（30.6%）患者在四次治疗后反应较差或无反应。血清维生素 D 水平与治疗反应无明显关系。完全应答组的 TLR2 表达较高。 对于不同类型的皮肤疣，局部注射维生素 D 是一种安全、经济的治疗方法。患者血清中TLR2的表达可用于预测对局部注射维生素D治疗的反应，表达较高的患者反应较好。
{"title":"Assessment of peripheral blood toll-like receptor 2 expression and vitamin D serum level as predictors of response to intralesional vitamin D in the treatment of warts","authors":"Eman M. K. Sanad, Rana R. Sanad, Amany K Shahat, Ahmed M. Hamed","doi":"10.4103/jewd.jewd_82_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_82_23","url":null,"abstract":"\u0000 \u0000 Warts are common dermatological conditions caused by human papilloma virus. Most treatments for human papilloma virus rely on the destruction of involved tissue. The role of vitamin D injection in treating warts is thought to be via regulating cell proliferation and differentiation through the upregulation of vitamin D receptors and the induction of antimicrobial peptides.\u0000 \u0000 \u0000 \u0000 To assess the clinical efficacy and safety of intralesional vitamin D in the treatment of cutaneous warts and also the significance of peripheral blood toll-like receptors 2 (TLR2) expression and serum levels of 25-hydroxyvitamin D in predicting the therapeutic success.\u0000 \u0000 \u0000 \u0000 In this prospective interventional study, 50 patients of cutaneous warts were subjected to history taking, proper dermatological examination, and peripheral venous blood collection for detection of TLR2 mRNA expression and a serum level of 25 (OH) D. Vitamin D3 was slowly injected into the base of the largest or the oldest wart at 2-week intervals.\u0000 \u0000 \u0000 \u0000 A total of 34 (69.4%) patients showed response to intralesional Vitamin D [21 (42.9%) showed complete resolution of all lesions, 13 (26.5%) showed partial clearing] and 15 (30.6%) patients showed poor or no response after four sessions. Serum level of vitamin D did not show a significant relation with treatment response. TLR2 expression was higher in the group showing complete response.\u0000 \u0000 \u0000 \u0000 Intralesional vitamin D injection offers a safe and cost-effective therapy for different types of cutaneous warts. TLR2 expression in patients’ serum can be used to predict response to treatment by intralesional vitamin D, with better response in patients with higher expression.\u0000","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141053070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Galal El Enany, N. Nagui, H. Nada, Mona R. E. Abdel‐Halim, Iman Sany, Ahmad Nada, Omar El Ghanam, M. Korany
Mastocytosis is a disorder characterized by abnormal mast cell proliferation. The skin is the most common site of involvement. Extracutaneous involvement occurs in systemic mastocytosis with infiltrations in the gastrointestinal tract, lymph nodes, bone marrow, liver, and spleen which result in systemic manifestations and life-threatening complications. The most common form of skin lesions in mastocytosis is urticaria pigmentosa (UP). Other less common forms include diffuse cutaneous mastocytosis (DCM), mastocytoma and telangiectasia macularis eruptive perstans (TMEP). Bullae can develop in skin lesions of mastocytosis. When bullae are the main presenting feature, the term bullous mastocytosis is used. Bullous mastocytosis can cause diagnostic confusion as it can be mistaken with other bullous skin diseases. Herein we present a case of bullous mastocytosis that was initially thought to be a form of child abuse. We emphasize the importance of skin biopsy in the diagnosis of this form of mastocytosis..
{"title":"Bullous mastocytosis: a Case Report","authors":"Galal El Enany, N. Nagui, H. Nada, Mona R. E. Abdel‐Halim, Iman Sany, Ahmad Nada, Omar El Ghanam, M. Korany","doi":"10.4103/jewd.jewd_66_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_66_23","url":null,"abstract":"Mastocytosis is a disorder characterized by abnormal mast cell proliferation. The skin is the most common site of involvement. Extracutaneous involvement occurs in systemic mastocytosis with infiltrations in the gastrointestinal tract, lymph nodes, bone marrow, liver, and spleen which result in systemic manifestations and life-threatening complications. The most common form of skin lesions in mastocytosis is urticaria pigmentosa (UP). Other less common forms include diffuse cutaneous mastocytosis (DCM), mastocytoma and telangiectasia macularis eruptive perstans (TMEP). Bullae can develop in skin lesions of mastocytosis. When bullae are the main presenting feature, the term bullous mastocytosis is used. Bullous mastocytosis can cause diagnostic confusion as it can be mistaken with other bullous skin diseases. Herein we present a case of bullous mastocytosis that was initially thought to be a form of child abuse. We emphasize the importance of skin biopsy in the diagnosis of this form of mastocytosis..","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pankaj Das, B. Vasudevan, Gautam K. Singh, Lekshmi P. Krishnan, Anand Mannu, D. Mitra
{"title":"Rituximab infusion: dumping the conventional drip for infusion pump","authors":"Pankaj Das, B. Vasudevan, Gautam K. Singh, Lekshmi P. Krishnan, Anand Mannu, D. Mitra","doi":"10.4103/jewd.jewd_69_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_69_23","url":null,"abstract":"","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141026356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasmin B. El Zawahry, Bakr M. El Zawahry, Dalia A. Bassiouny, Ahmed M. Soliman, Heba M. Abdel-Raheem
Reports on the long-term treatment of alopecia areata (AA) in children with diphenylcyclopropenone (DPCP) are few. To assess response, side effects, and relapse rates during long-term follow-up in children with severe AA treated with DPCP. Effect of different patient and treatment-related factors on prognosis and value of maintenance therapy were also assessed. In this interventional prospective study, 144 patients of AA were treated with DPCP. Response was assessed according to sex, type of AA, age of onset, and duration of disease. Excellent response was defined as terminal hair covering more than 75% of the scalp. Maintenance therapy meant ongoing therapy once every 2–4 weeks after excellent response. Follow up for an average of 22 months was performed to detect any relapse of AA which meant more than 25% hair loss. Ninety-two patients completed 12 months of therapy. Thirty (32.6%) patients achieved excellent response, 33 (35.9%) moderate, and 29 (31.5%) poor response. Seventy-three patients completed 18 months of therapy. Fouty-eight (65.8%) achieved excellent response, 10 (13.7%) moderate, and 15 (20.5%) poor response. Different clinical variables did not affect the response, however, a significant difference in the beginning of terminal hair growth according to type of AA was found (P=0.002) where 10% of responders among alopecia universalis patients started to grow terminal hair more than 12 months after the onset of therapy. Side effects were few and tolerable. Relapse occurred in 47% of patients on maintenance and 78% of patients without maintenance therapy (P=0.048). DPCP is an effective and safe treatment of severe AA in children. Prolonging the duration of therapy may improve the response in alopecia universalis and alopecia totalis. Maintenance therapy is recommended to reduce the risk of relapse.
{"title":"Diphenylcyclopropenone in severe alopecia areata in children and adolescents: long-term follow-up and relapse rate","authors":"Yasmin B. El Zawahry, Bakr M. El Zawahry, Dalia A. Bassiouny, Ahmed M. Soliman, Heba M. Abdel-Raheem","doi":"10.4103/jewd.jewd_89_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_89_23","url":null,"abstract":"\u0000 \u0000 Reports on the long-term treatment of alopecia areata (AA) in children with diphenylcyclopropenone (DPCP) are few.\u0000 \u0000 \u0000 \u0000 To assess response, side effects, and relapse rates during long-term follow-up in children with severe AA treated with DPCP. Effect of different patient and treatment-related factors on prognosis and value of maintenance therapy were also assessed.\u0000 \u0000 \u0000 \u0000 In this interventional prospective study, 144 patients of AA were treated with DPCP. Response was assessed according to sex, type of AA, age of onset, and duration of disease. Excellent response was defined as terminal hair covering more than 75% of the scalp. Maintenance therapy meant ongoing therapy once every 2–4 weeks after excellent response. Follow up for an average of 22 months was performed to detect any relapse of AA which meant more than 25% hair loss.\u0000 \u0000 \u0000 \u0000 Ninety-two patients completed 12 months of therapy. Thirty (32.6%) patients achieved excellent response, 33 (35.9%) moderate, and 29 (31.5%) poor response. Seventy-three patients completed 18 months of therapy. Fouty-eight (65.8%) achieved excellent response, 10 (13.7%) moderate, and 15 (20.5%) poor response. Different clinical variables did not affect the response, however, a significant difference in the beginning of terminal hair growth according to type of AA was found (P=0.002) where 10% of responders among alopecia universalis patients started to grow terminal hair more than 12 months after the onset of therapy. Side effects were few and tolerable. Relapse occurred in 47% of patients on maintenance and 78% of patients without maintenance therapy (P=0.048).\u0000 \u0000 \u0000 \u0000 DPCP is an effective and safe treatment of severe AA in children. Prolonging the duration of therapy may improve the response in alopecia universalis and alopecia totalis. Maintenance therapy is recommended to reduce the risk of relapse.\u0000","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141056722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Doss, L. A. Rashed, Hanaa Ibrahim, R. M. Naguib
Vitiligo is a skin disease that is characterized by depigmenting lesions as a result of melanocytes destruction. Long noncoding Taurine upregulated gene 1 (lnc TUG-1) is one of the long noncoding RNA (lnc RNA) family members. The role of lncRNA TUG1 in melanogenesis has been investigated in recent studies. To investigate the impact of narrow-band ultraviolet B (NB-UVB) on lncTUG-1 expression in vitiligo. The first step of this work was a case control study that included thirty vitiligo patients and thirty healthy controls. four mm skin biopsies were taken from normal skin in healthy controls and from depigmenting lesions in vitiligo patients. The second step was a prospective single-arm interventional study in which patients were subjected to 12 weeks of NB-UVB phototherapy and biopsies were taken from repigmenting areas. Biopsies were kept frozen at −80°C till by real-time polymerase chain reaction was conducted to evaluate the lnc TUG-1 expression. The mean lnc TUG-1 expression in skin tissue biopsies of the vitiligo patients was significantly lower compared with control skin biopsies (0.307±0.202 ng/mg vs 1.03±0.063 pg/mg, respectively, P<0.001). Although the level of lnc TUG-1 was not normalized, the mean value of lnc TUG-1 significantly increased after 12 weeks treatment with NB-UVB compared with its value before phototherapy (0.0687 ng/mg vs. 0.307 ng/mg, respectively, P<0.001). The lnc TUG-1 could be a possible player in the pathogenesis of vitiligo and repigmentation of vitiligo after NB-UVB phototherapy.
{"title":"Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo","authors":"R. Doss, L. A. Rashed, Hanaa Ibrahim, R. M. Naguib","doi":"10.4103/jewd.jewd_76_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_76_23","url":null,"abstract":"\u0000 \u0000 Vitiligo is a skin disease that is characterized by depigmenting lesions as a result of melanocytes destruction. Long noncoding Taurine upregulated gene 1 (lnc TUG-1) is one of the long noncoding RNA (lnc RNA) family members. The role of lncRNA TUG1 in melanogenesis has been investigated in recent studies.\u0000 \u0000 \u0000 \u0000 To investigate the impact of narrow-band ultraviolet B (NB-UVB) on lncTUG-1 expression in vitiligo.\u0000 \u0000 \u0000 \u0000 The first step of this work was a case control study that included thirty vitiligo patients and thirty healthy controls. four mm skin biopsies were taken from normal skin in healthy controls and from depigmenting lesions in vitiligo patients. The second step was a prospective single-arm interventional study in which patients were subjected to 12 weeks of NB-UVB phototherapy and biopsies were taken from repigmenting areas. Biopsies were kept frozen at −80°C till by real-time polymerase chain reaction was conducted to evaluate the lnc TUG-1 expression.\u0000 \u0000 \u0000 \u0000 The mean lnc TUG-1 expression in skin tissue biopsies of the vitiligo patients was significantly lower compared with control skin biopsies (0.307±0.202 ng/mg vs 1.03±0.063 pg/mg, respectively, P<0.001). Although the level of lnc TUG-1 was not normalized, the mean value of lnc TUG-1 significantly increased after 12 weeks treatment with NB-UVB compared with its value before phototherapy (0.0687 ng/mg vs. 0.307 ng/mg, respectively, P<0.001).\u0000 \u0000 \u0000 \u0000 The lnc TUG-1 could be a possible player in the pathogenesis of vitiligo and repigmentation of vitiligo after NB-UVB phototherapy.\u0000","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Randa Youssef, Nourhan Emad, Olfat Shaker, R. Mogawer
Vitiligo is an acquired depigmenting skin disorder in which CD8 effector and memory T-cells contribute to its pathogenesis and recurrence. Interleukin (IL)-15 contributes to CD8 effector T-cell cytotoxicity and CD8 memory T-cell survival and maturation. To evaluate the effect of total narrowband ultraviolet B (NB-UVB) on tissue levels of IL-15 and IL-15 receptor alpha (IL-15Ra) in active nonsegmental vitiligo. The patients were assessed clinically for vitiligo extent and activity before and after treatment. Perilesional skin biopsies were taken from 30 vitiligo patients before and after 48 sessions of NB-UVB and from 30 healthy controls. Tissue levels of IL-15 and IL-15 Ra were evaluated by enzyme-linked immunosorbent assay before and after treatment to evaluate the effect of NB-UVB on them. Before NB-UVB treatment, the tissue levels of both IL-15 and IL-15Ra were significantly higher in vitiligo patients than controls; moreover, they were significantly higher than those after NB-UVB treatment. In contrast, after NB-UVB treatment, no statistically significant difference was detected between the patients and controls. The levels of IL-15 and IL-15Ra were significantly correlated, whereas they were not correlated with either vitiligo activity or extent. IL-15 and IL-15Ra were higher in vitiligo patients than controls before treatment. However, their tissue levels were normalized after treatment with NB-UVB, emphasizing its therapeutic potential.
{"title":"The effect of narrowband ultraviolet B on tissue level of interleukin-15 and interleukin-15 receptor alpha subunit in active nonsegmental vitiligo cases: an interventional cohort study","authors":"Randa Youssef, Nourhan Emad, Olfat Shaker, R. Mogawer","doi":"10.4103/jewd.jewd_77_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_77_23","url":null,"abstract":"\u0000 \u0000 Vitiligo is an acquired depigmenting skin disorder in which CD8 effector and memory T-cells contribute to its pathogenesis and recurrence. Interleukin (IL)-15 contributes to CD8 effector T-cell cytotoxicity and CD8 memory T-cell survival and maturation.\u0000 \u0000 \u0000 \u0000 To evaluate the effect of total narrowband ultraviolet B (NB-UVB) on tissue levels of IL-15 and IL-15 receptor alpha (IL-15Ra) in active nonsegmental vitiligo.\u0000 \u0000 \u0000 \u0000 The patients were assessed clinically for vitiligo extent and activity before and after treatment. Perilesional skin biopsies were taken from 30 vitiligo patients before and after 48 sessions of NB-UVB and from 30 healthy controls. Tissue levels of IL-15 and IL-15 Ra were evaluated by enzyme-linked immunosorbent assay before and after treatment to evaluate the effect of NB-UVB on them.\u0000 \u0000 \u0000 \u0000 Before NB-UVB treatment, the tissue levels of both IL-15 and IL-15Ra were significantly higher in vitiligo patients than controls; moreover, they were significantly higher than those after NB-UVB treatment. In contrast, after NB-UVB treatment, no statistically significant difference was detected between the patients and controls. The levels of IL-15 and IL-15Ra were significantly correlated, whereas they were not correlated with either vitiligo activity or extent.\u0000 \u0000 \u0000 \u0000 IL-15 and IL-15Ra were higher in vitiligo patients than controls before treatment. However, their tissue levels were normalized after treatment with NB-UVB, emphasizing its therapeutic potential.\u0000","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141053687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Cacciapuoti, M. C. Annunziata, M. Megna, A. Villani, F. Martora, G. Fabbrocini, L. Potestio
Acne is a common skin disease, affecting millions of subjects worldwide. Several processes and mechanisms have been identified in acne pathogenesis. Among these, it is known that acne or its worsening is also related to metabolic factors and nutritional influences. In this scenario, we carried out a review of the current literature in order to investigate the role of diet in acne disease, offering a wide perspective for possible clinical applications. A total of 55 manuscripts were considered. In particular, the role of the Western diet, glycemic index, glycemic load, dairy products, fats, fatty acids, Mediterranean diet, ketogenic diet, and dietary supplements in acne management has been investigated. On one hand, dairy products, foods with high glycemic load and glycemic index, fatty acids and fats seem to worsen the severity; on the other hand, Mediterranean and ketogenic diet, and oral supplements seem to improve the disease. Despite the conflicting results and conclusions in the scientific literature about the impact of nutrition in acne, mainly related to the severla limitations of the study design, several prospective, controlled, well-designed studies have recently demonstrated the role of some specific nutrition influenced mediators on acne severity.
{"title":"Dietary intervention in acne management: review of the literature and future prospective","authors":"S. Cacciapuoti, M. C. Annunziata, M. Megna, A. Villani, F. Martora, G. Fabbrocini, L. Potestio","doi":"10.4103/jewd.jewd_46_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_46_23","url":null,"abstract":"Acne is a common skin disease, affecting millions of subjects worldwide. Several processes and mechanisms have been identified in acne pathogenesis. Among these, it is known that acne or its worsening is also related to metabolic factors and nutritional influences. In this scenario, we carried out a review of the current literature in order to investigate the role of diet in acne disease, offering a wide perspective for possible clinical applications. A total of 55 manuscripts were considered. In particular, the role of the Western diet, glycemic index, glycemic load, dairy products, fats, fatty acids, Mediterranean diet, ketogenic diet, and dietary supplements in acne management has been investigated. On one hand, dairy products, foods with high glycemic load and glycemic index, fatty acids and fats seem to worsen the severity; on the other hand, Mediterranean and ketogenic diet, and oral supplements seem to improve the disease. Despite the conflicting results and conclusions in the scientific literature about the impact of nutrition in acne, mainly related to the severla limitations of the study design, several prospective, controlled, well-designed studies have recently demonstrated the role of some specific nutrition influenced mediators on acne severity.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reham L. Gohar, B. Mourad, N. Sarhan, E. S. E. Shaker
Psoriasis is a chronic, recurring, and immune-mediated inflammatory skin disease. Throughout the period of the last few decades, phototherapy has become widely used in treating stable psoriatic lesions. For the treatment of psoriasis, several light/laser therapies with distinct modes of action have been developed. Cold laser therapy might be an effective therapeutic choice for localized plaque psoriasis. To assess the safety and efficacy of cold laser therapy clinically and microscopically in localized plaque psoriasis treatment. 40 patients with localized mild plaque psoriasis were selected from the Dermatology and Venereology outpatient clinic–Tanta University Hospitals and enrolled in the clinical trial. They were treated by cold laser 808 nm wavelength (Endolaser 422, Enraf–nonious B.V. Rotterdam, Netherlands) one session for 10 min on each plaque twice weekly separated by 2 days until clinical cure or for a maximum of 8 weeks. Evaluation was done immediately after the last session by taking the average of three blinded dermatologists of the photos, the modified Psoriasis Area and Severity Index [mPASI], dermoscopic examination, patients’ satisfaction scale and histopathological and electron microscopic examination of punch biopsy specimens taken before and after the end of treatment from psoriatic lesions in four patients only. There was a statistically significant clinical improvement after the end of treatment compared with before treatment as 16 patients (40%) showed excellent improvement, 8 patients (20%) showed good improvement, 9 patients (22.5%) showed mild improvement, and 7 patients (17.5%) showed poor improvement. As regard mPASI, a statistically significant decrease in mPASI was found after the end of treatment (P<0.001). Regarding dermoscopic examination, a statistically significant reduction in the percentage of patients showing dermoscopic red dots and white scales after the end of treatment (P<0.01). As regard the patients’ satisfaction scale, 82.5% of patients were satisfied from the results. Histopathological and ultrastructural evaluation revealed normalization of the psoriatic microscopic changes with cold laser. The use of cold laser therapy for the management of localized mild plaque psoriasis is safe, tolerable, effective, and can be used as an alternative therapy for psoriasis.
{"title":"Evaluation of the efficacy and safety of cold laser (Diode 808 nm) therapy in the treatment of localized plaque psoriasis: clinical, dermoscopic and ultrastructural study","authors":"Reham L. Gohar, B. Mourad, N. Sarhan, E. S. E. Shaker","doi":"10.4103/jewd.jewd_47_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_47_23","url":null,"abstract":"\u0000 \u0000 Psoriasis is a chronic, recurring, and immune-mediated inflammatory skin disease. Throughout the period of the last few decades, phototherapy has become widely used in treating stable psoriatic lesions. For the treatment of psoriasis, several light/laser therapies with distinct modes of action have been developed. Cold laser therapy might be an effective therapeutic choice for localized plaque psoriasis.\u0000 \u0000 \u0000 \u0000 To assess the safety and efficacy of cold laser therapy clinically and microscopically in localized plaque psoriasis treatment.\u0000 \u0000 \u0000 \u0000 40 patients with localized mild plaque psoriasis were selected from the Dermatology and Venereology outpatient clinic–Tanta University Hospitals and enrolled in the clinical trial. They were treated by cold laser 808 nm wavelength (Endolaser 422, Enraf–nonious B.V. Rotterdam, Netherlands) one session for 10 min on each plaque twice weekly separated by 2 days until clinical cure or for a maximum of 8 weeks. Evaluation was done immediately after the last session by taking the average of three blinded dermatologists of the photos, the modified Psoriasis Area and Severity Index [mPASI], dermoscopic examination, patients’ satisfaction scale and histopathological and electron microscopic examination of punch biopsy specimens taken before and after the end of treatment from psoriatic lesions in four patients only.\u0000 \u0000 \u0000 \u0000 There was a statistically significant clinical improvement after the end of treatment compared with before treatment as 16 patients (40%) showed excellent improvement, 8 patients (20%) showed good improvement, 9 patients (22.5%) showed mild improvement, and 7 patients (17.5%) showed poor improvement. As regard mPASI, a statistically significant decrease in mPASI was found after the end of treatment (P<0.001). Regarding dermoscopic examination, a statistically significant reduction in the percentage of patients showing dermoscopic red dots and white scales after the end of treatment (P<0.01). As regard the patients’ satisfaction scale, 82.5% of patients were satisfied from the results. Histopathological and ultrastructural evaluation revealed normalization of the psoriatic microscopic changes with cold laser.\u0000 \u0000 \u0000 \u0000 The use of cold laser therapy for the management of localized mild plaque psoriasis is safe, tolerable, effective, and can be used as an alternative therapy for psoriasis.\u0000","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141034801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Plantar warts are benign epithelial tumors that are forced inward due to pressure on the toes or sole of the foot and may become very painful if not treated. Many treatment options are available including topical treatments, lasers, and immunotherapy. However, data about systemic therapies are lacking. To compare the efficacy and safety of acitretin versus oral isotretinoin in the treatment of multiple plantar warts. This randomized comparative double-blinded study included 80 adult patients with multiple plantar warts. The cases were divided into two groups: acitretin group (40 cases with a dose of 0.5 mg/kg/day) and isotretinoin group (40 cases with a dose of 0.5 mg/kg/day). The reduction in wart size and photographic comparisons at the beginning and every 2 weeks for 3 months were used to assess the treatment efficacy in the two groups. After therapy ended, a follow-up was conducted every month for 6 months to observe any recurrence. Complete response was observed in 30%, partial response in 55%, and no response in 15% of patients of acitretin group while complete response was achieved in 15%, partial response in 45%, and no response in 40% of patients of isotretinoin group with statistically significant difference in favor of acitretin (P=0.03). Compared with acitretin, oral isotretinoin was associated with a shorter duration to a complete response (83.3% of cases achieved complete response in <2 months compared with only 16.7% in acitretin group) (P=0.006). Acitretin is superior to oral isotretinoin as a therapeutic option for plantar warts, but both are effective and safe. Since they are resistant to other traditional therapy techniques, they can be seen as valuable therapeutic choices for multiple plantar warts.
{"title":"Oral isotretinoin versus acitretin in the treatment of plantar warts in adults","authors":"Ahmad A.E. Nofal, S. M. Najah, Ahmed S.A. ElShafy","doi":"10.4103/jewd.jewd_55_23","DOIUrl":"https://doi.org/10.4103/jewd.jewd_55_23","url":null,"abstract":"\u0000 \u0000 Plantar warts are benign epithelial tumors that are forced inward due to pressure on the toes or sole of the foot and may become very painful if not treated. Many treatment options are available including topical treatments, lasers, and immunotherapy. However, data about systemic therapies are lacking.\u0000 \u0000 \u0000 \u0000 To compare the efficacy and safety of acitretin versus oral isotretinoin in the treatment of multiple plantar warts.\u0000 \u0000 \u0000 \u0000 This randomized comparative double-blinded study included 80 adult patients with multiple plantar warts. The cases were divided into two groups: acitretin group (40 cases with a dose of 0.5 mg/kg/day) and isotretinoin group (40 cases with a dose of 0.5 mg/kg/day). The reduction in wart size and photographic comparisons at the beginning and every 2 weeks for 3 months were used to assess the treatment efficacy in the two groups. After therapy ended, a follow-up was conducted every month for 6 months to observe any recurrence.\u0000 \u0000 \u0000 \u0000 Complete response was observed in 30%, partial response in 55%, and no response in 15% of patients of acitretin group while complete response was achieved in 15%, partial response in 45%, and no response in 40% of patients of isotretinoin group with statistically significant difference in favor of acitretin (P=0.03). Compared with acitretin, oral isotretinoin was associated with a shorter duration to a complete response (83.3% of cases achieved complete response in <2 months compared with only 16.7% in acitretin group) (P=0.006).\u0000 \u0000 \u0000 \u0000 Acitretin is superior to oral isotretinoin as a therapeutic option for plantar warts, but both are effective and safe. Since they are resistant to other traditional therapy techniques, they can be seen as valuable therapeutic choices for multiple plantar warts.\u0000","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141041251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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