血浆钙、磷、碱性磷酸酶和甲状旁腺激素在预测维生素D缺乏中的作用

Q3 Biochemistry, Genetics and Molecular Biology Journal of Advanced Biotechnology and Experimental Therapeutics Pub Date : 2023-01-01 DOI:10.5455/jabet.2023.d135
R. Hashim, Israa Nathir, E. Ghazy, Ihsan Timimi, Tiba M. Hameed, Mayssam Ali
{"title":"血浆钙、磷、碱性磷酸酶和甲状旁腺激素在预测维生素D缺乏中的作用","authors":"R. Hashim, Israa Nathir, E. Ghazy, Ihsan Timimi, Tiba M. Hameed, Mayssam Ali","doi":"10.5455/jabet.2023.d135","DOIUrl":null,"url":null,"abstract":"Vitamin D deficiency is a highly prevalent medical condition associated with various clinical and biochemical outcomes although these outcomes might be absent in a significant percentage of patients. Altered serum calcium, phosphorus, parathyroid hormone and alkaline phosphatase activity are expected but not proven by many research. The current study aims to investigate the possibility of these biomarkers to be used as indicators of vitamin D deficiency or insufficiency. The study enrolled 150 randomly selected participants who have no acute or chronic medical condition with various levels of serum vitamin D ranging from normal to severely deficient. They were investigated for serum total calcium, phosphorus, parathyroid hormone and alkaline phosphatase activity. The results were statistically compared among the studied groups and correlated with serum vitamin D levels. There was no significant difference in mean serum calcium, phosphorus and alkaline phosphatase activity among the groups with poor correlation with vitamin D. Mean serum parathyroid hormone has shown a significant difference among the studied groups with a strong negative correlation with vitamin D. This difference was apparent even in patients with vitamin D insufficiency. Serum calcium, PO4 and ALP activity seem to have a poor correlation with vitamin D concentration. In addition, serum PTH might be considered a sensitive marker of both vitamin D deficiency and insufficiency.","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of plasma calcium, phosphorus, alkaline phosphatase, and parathyroid ‎hormone in the prediction of vitamin D deficiency‎\",\"authors\":\"R. Hashim, Israa Nathir, E. Ghazy, Ihsan Timimi, Tiba M. Hameed, Mayssam Ali\",\"doi\":\"10.5455/jabet.2023.d135\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Vitamin D deficiency is a highly prevalent medical condition associated with various clinical and biochemical outcomes although these outcomes might be absent in a significant percentage of patients. Altered serum calcium, phosphorus, parathyroid hormone and alkaline phosphatase activity are expected but not proven by many research. The current study aims to investigate the possibility of these biomarkers to be used as indicators of vitamin D deficiency or insufficiency. The study enrolled 150 randomly selected participants who have no acute or chronic medical condition with various levels of serum vitamin D ranging from normal to severely deficient. They were investigated for serum total calcium, phosphorus, parathyroid hormone and alkaline phosphatase activity. The results were statistically compared among the studied groups and correlated with serum vitamin D levels. There was no significant difference in mean serum calcium, phosphorus and alkaline phosphatase activity among the groups with poor correlation with vitamin D. Mean serum parathyroid hormone has shown a significant difference among the studied groups with a strong negative correlation with vitamin D. This difference was apparent even in patients with vitamin D insufficiency. Serum calcium, PO4 and ALP activity seem to have a poor correlation with vitamin D concentration. In addition, serum PTH might be considered a sensitive marker of both vitamin D deficiency and insufficiency.\",\"PeriodicalId\":36275,\"journal\":{\"name\":\"Journal of Advanced Biotechnology and Experimental Therapeutics\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Advanced Biotechnology and Experimental Therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5455/jabet.2023.d135\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Biotechnology and Experimental Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/jabet.2023.d135","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0

摘要

维生素D缺乏症是一种非常普遍的疾病,与各种临床和生化结果相关,尽管这些结果可能在很大比例的患者中不存在。血清钙、磷、甲状旁腺激素和碱性磷酸酶活性的改变是预期的,但尚未得到许多研究的证实。目前的研究旨在探讨这些生物标志物作为维生素D缺乏或不足的指标的可能性。该研究招募了150名随机选择的参与者,他们没有急性或慢性疾病,血清维生素D水平从正常到严重缺乏。测定血清总钙、总磷、甲状旁腺激素和碱性磷酸酶活性。结果在研究组之间进行统计学比较,并与血清维生素D水平相关。血清钙、磷、碱性磷酸酶活性均值在与维生素D相关性较差的组间无显著差异,血清甲状旁腺激素均值在与维生素D相关性较强的组间有显著差异,即使在维生素D不足的患者中也有明显差异。血清钙、PO4和ALP活性似乎与维生素D浓度相关性较差。此外,血清甲状旁腺激素可能被认为是维生素D缺乏和不足的敏感标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Role of plasma calcium, phosphorus, alkaline phosphatase, and parathyroid ‎hormone in the prediction of vitamin D deficiency‎
Vitamin D deficiency is a highly prevalent medical condition associated with various clinical and biochemical outcomes although these outcomes might be absent in a significant percentage of patients. Altered serum calcium, phosphorus, parathyroid hormone and alkaline phosphatase activity are expected but not proven by many research. The current study aims to investigate the possibility of these biomarkers to be used as indicators of vitamin D deficiency or insufficiency. The study enrolled 150 randomly selected participants who have no acute or chronic medical condition with various levels of serum vitamin D ranging from normal to severely deficient. They were investigated for serum total calcium, phosphorus, parathyroid hormone and alkaline phosphatase activity. The results were statistically compared among the studied groups and correlated with serum vitamin D levels. There was no significant difference in mean serum calcium, phosphorus and alkaline phosphatase activity among the groups with poor correlation with vitamin D. Mean serum parathyroid hormone has shown a significant difference among the studied groups with a strong negative correlation with vitamin D. This difference was apparent even in patients with vitamin D insufficiency. Serum calcium, PO4 and ALP activity seem to have a poor correlation with vitamin D concentration. In addition, serum PTH might be considered a sensitive marker of both vitamin D deficiency and insufficiency.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Advanced Biotechnology and Experimental Therapeutics
Journal of Advanced Biotechnology and Experimental Therapeutics Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.90
自引率
0.00%
发文量
41
审稿时长
8 weeks
期刊最新文献
Assessment of antiproliferative and toxic effects of a peptide from Momordica dioica using in vitro and in vivo studies Investigation of the relationship between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase with SARS CoV-2 infections Anti-inflammatory and anti-microbial activities of the phytochemicals isolated from various parts of broccoli wastes Epidemiological burden, risk factors, and recent therapeutic advances in chronic obstructive pulmonary disease The potentials of Pangi leaf extract for Aedes spp. mosquito control
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1