特发性炎性肌病:最新进展

B. Kurt, S. Taşdemir, E. Çelik, K. Inan
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摘要

特发性炎症性肌病(IIM)是一种具有复杂临床特征的异质性疾病。它已被细分为:(1)皮肌炎,(2)多肌炎和(3)包体体肌炎(IBM)。目前已有文献研究认为,坏死性自身免疫性肌病和免疫介导性坏死性肌病也应加入到这一类疾病中。关于IIMs的诊断存在争议,到目前为止,已经提出了大约12种标准体系。一些标准系统已被广泛使用,如Griggs等人为IBM提出的建议。临床表现、自身抗体、酶、电生理和肌肉活检结果是诊断工具。由于疾病的复杂性,这些发现都不能单独用于诊断。在本研究中,我们讨论了IMMs的诊断标准,并描述了详细的形态学特征。
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Idiopathic Inflammatory Myopathies: An update -
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disease with complex clinical features. It has been sub-classified as: (1) Dermatomyositis, (2) Polymyositis, and (3) Inclusion body myositis (IBM). Nowadays, there are some studies in literature suggest necrotizing autoimmune myopathy and immune-mediated necrotizing myopathy should also be added to this group of disease. There is a debate in the diagnosis of IIMs and up until now, about 12 criteria systems have been proposed. Some of the criteria systems have been used widely such as Griggs et al.’s proposal for IBM. Clinical findings, autoantibodies, enzymes, electrophysiological, and muscle biopsy findings are diagnostic tools. Because of diseases’ complexity, none of the findings are diagnostic alone. In this study, we discussed the diagnostic criteria of IMMs and described detailed morphological features.
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