金属髋关节置换术的个性化医疗:伯明翰髋关节置换术10年成功的预测因素

J. Kuiper, P. Lee, P. Heaton, A. Qureshi, J. Richardson
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引用次数: 0

摘要

背景:引入金属对金属髋关节置换术以保护患者的骨骼并方便翻修手术。本前瞻性队列研究旨在确定预后模型(OsBHR),以预测哪些患者和外科医生相关因素可以预测伯明翰髋关节置换术(BHR)的长期植入物存活率。方法:1997年至2002年间,4490例(4945髋)采用BHR人工髋关节置换术进行髋关节表面置换术的患者的详细资料被纳入前瞻性国际登记并可用于分析。使用Kaplan-Meier估计器确定种植体存活,并使用共享脆弱比例风险模型确定种植体翻修的预测因子。结果:预后方程提示,男性患者应使用最小直径50 mm,女性患者应使用最小直径52 mm,以确保由普通外科医生进行的手术的最低10年生存率为95%。结论:种植体10年及以上的存活率与种植体的大小和性别有很大的关系,不同的外科医生有不同的差异,但受患者年龄的影响很小。OsBHR预测器允许基于术前变量的个性化估计10年生存率。
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Personalized Medicine for Metal on Metal Hip Resurfacing: Predictors for the 10 Years Success of the Birmingham Hip Resurfacing
Background: Metal-on-metal hip resurfacing arthroplasty was introduced to preserve patients’ bone and facilitate revision surgery. This prospective cohort study aims to determine a prognostic model (OsBHR) to predict which patient and surgeon related factors predict better long term implant survival for the Birmingham Hip Resurfacing (BHR). Methods: Between 1997 and 2002, details of 4490 patients (4945 hips) treated by hip resurfacing arthroplasty using the BHR prosthesis were entered in a prospective international registry and available for analysis. Implant survival was determined using the Kaplan-Meier estimator and a shared frailty proportional hazard model was used to determine predictors of implant revision. Results: prognostic equation suggested a minimum diameter of 50 mm should be used for male and 52 mm for female patients to ensure a minimum 10-year survival rate of 95% for in procedures performed by an average surgeon. Conclusion: Implant survival at ten years and beyond strongly depends on component size and gender, varies between surgeons but is little affected by patient age. The OsBHR predictor allows a personalized estimated survival at ten years based on pre-operative variables.
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