格雷夫斯病抗甲状腺治疗的血液学图像综述

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI:10.5937/afmnai39-36192
Aksanur Gokce, T. Omma, Mustafa Çelikc, I. Taşkaldıran
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引用次数: 0

摘要

目的:Graves病是一种自身免疫性甲状腺疾病,是甲状腺功能亢进的最常见原因。外周血细胞参数如中性粒细胞、淋巴细胞和血小板在炎症控制中起作用。多项研究证实,中性粒细胞-淋巴细胞比率、单核细胞-淋巴细胞比率和血小板-淋巴细胞比率是多种疾病慢性亚临床炎症的指标。在我们的研究中,我们旨在通过评估Graves病患者抗甲状腺治疗前后的这些参数来回顾外周血图像。患者和方法:共纳入120例患者,其中女性93例,男性27例,年龄18-65岁。回顾性记录患者在诊断时及经治疗后甲状腺功能恢复正常时的人口学资料、血象及生化指标。结果:治疗期间,血红蛋白、淋巴细胞、中性粒细胞及红细胞分布宽度增加,单核细胞减少。白细胞、血小板及平均血小板体积差异无统计学意义。甲状腺功能正常后中性粒细胞-淋巴细胞比值(p = 0.8)和血小板-淋巴细胞比值(p = 0.078)差异无统计学意义,单核细胞-淋巴细胞比值下降有统计学意义(p = 0.006)。结论:造血功能改变在新诊断的Graves病患者中较为常见,抗甲状腺治疗的开始可改善这些参数。虽然中性粒细胞-淋巴细胞比率、单核细胞-淋巴细胞比率和血小板-淋巴细胞比率被认为是临床评估中新的、无创的指标,但在我们的研究中,只有在抗甲状腺治疗达到甲状腺功能正常后,单核细胞-淋巴细胞比率水平才有显著下降。
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An overview of the hematological picture with antithyroid therapy in Graves' disease
Aim: Graves' disease is an autoimmune thyroid disease that is the most common cause of hyperthyroidism. Peripheral blood cell parameters such as neutrophils, lymphocytes, and platelets play a role in inflammation control. Several studies have proven that neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio are indicators of chronic subclinical inflammation in various diseases. In our study, we aimed to review the peripheral blood picture by evaluating these parameters before and after antithyroid treatment in patients with Graves' disease. Patients and methods: A total of 120 patients (93 female, 27 male) between the ages of 18-65 were included. Demographic data, hemogram and biochemical data of the patients were recorded retrospectively at the time of diagnosis and after euthyroidism was achieved with medical treatment. Results: During the treatment, there was an increase in hemoglobin, lymphocytes, neutrophils and red cell distribution width, while a decrease in monocytes was observed. There was no significant difference between white blood cell, platelet and mean platelet volume. In addition, while there was no statistically significant difference between neutrophil-lymphocyte ratio (p = 0.8) and thrombocyt-lymphocyte ratio (p = 0.078) after euthyroid state, a statistically significant difference was found in favor of a decrease in monocyte-lymphocyte ratio (p = 0.006). Conclusion: Changes in hematopoiesis are relatively common in patients with newly diagnosed Graves' disease, and initiation of antithyroid therapy leads to improvement in these parameters. Although neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio are accepted as new, non-invasive markers in clinical evaluation, in our study only a significant decrease in monocyte-lymphocyte ratio levels was observed after euthyroidism was achieved with antithyroid treatment.
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来源期刊
Acta Facultatis Medicae Naissensis
Acta Facultatis Medicae Naissensis MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
0.00%
发文量
13
审稿时长
12 weeks
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