Mona Esbjörnsson, Barbara Norman, Moa Persson, Amarjit Saini, Jens Bülow, Eva Jansson
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AT venous IL-6 increased 15-fold from 0.4 ± 0.4 at rest to 7.0 ± 4 pg × mL<sup>−1</sup> (<i>p</i> < 0.0001) and AT v–a difference increased 45-fold from 0.12 ± 0.3 to 6.0 ± 5 pg x mL<sup>−1</sup> (<i>p</i> < 0.0001) 9 min after last sprint. Arterial glycerol increased 2.5-fold from rest to 9 min postsprint 1 (<i>p</i> < 0.0001) and was maintained during the exercise period. AT venous and v–a difference of glycerol increased 2-fold from rest to 9 min postsprint 1 (<i>p</i> < 0.0001 and <i>p</i> = 0.01, respectively), decreased until 18 min postsprint 2 (<i>p</i> < 0.001 and <i>p</i> < 0.0001), and then increased again until 9 min after last sprint (both <i>p</i> < 0.01).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The concurrent increase in venous IL-6 and glycerol in AT after last sprint is consistent with an IL-6 induced lipolysis in AT. Glycerol data also indicated an initial increase in lipolysis after sprint 1 that was unrelated to IL-6. Increased IL-6 in adipose tissue may, therefore, complement other sprint exercise-induced lipolytic agents.</p>\n </section>\n </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"44 2","pages":"171-178"},"PeriodicalIF":1.3000,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12863","citationCount":"0","resultStr":"{\"title\":\"Enhanced interleukin-6 in human adipose tissue vein after sprint exercise: Results from a pilot study\",\"authors\":\"Mona Esbjörnsson, Barbara Norman, Moa Persson, Amarjit Saini, Jens Bülow, Eva Jansson\",\"doi\":\"10.1111/cpf.12863\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Low-volume sprint exercise is likely to reduce body fat. Interleukin (IL-6) may mediate this by increasing adipose tissue (AT) lipolysis. 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AT venous and v–a difference of glycerol increased 2-fold from rest to 9 min postsprint 1 (<i>p</i> < 0.0001 and <i>p</i> = 0.01, respectively), decreased until 18 min postsprint 2 (<i>p</i> < 0.001 and <i>p</i> < 0.0001), and then increased again until 9 min after last sprint (both <i>p</i> < 0.01).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>The concurrent increase in venous IL-6 and glycerol in AT after last sprint is consistent with an IL-6 induced lipolysis in AT. Glycerol data also indicated an initial increase in lipolysis after sprint 1 that was unrelated to IL-6. 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引用次数: 0
摘要
背景：小容量的短跑运动可能会减少身体脂肪。白细胞介素（IL-6）可能通过增加脂肪组织脂解来介导这种情况。因此，在进行三次30秒全力冲刺的10名健康受试者中，检测了脂肪组织（AT）IL-6和甘油（脂解的标志物）的交换。方法：在最后一次冲刺后9分钟内，从腹前壁的肱动脉（a）和皮下浅静脉（v）采集血样，并分析IL-6和甘油。结果：从休息到最后冲刺，动脉IL-6增加了2倍。AT静脉IL-6从静止时的0.4±0.4增加到7.0±4 pg x mL-1，增加了15倍（P＜0.0001），AT v-a差异从0.12±0.3增加到6.0±5 pg x mL-，增加了45倍（P＞0.0001）。从休息到冲刺1后9分钟，动脉甘油增加了2.5倍（P<0.0001），并在运动期间保持不变。从静止到冲刺1后9分钟，AT静脉和v-a甘油的差异增加了2倍（分别为P＜0.0001和P＝0.01），直到冲刺2后18分钟才降低（P＜0.001和P＜0.00001），结论：最后一次冲刺后脂肪组织中静脉IL-6和甘油的同时增加与IL-6诱导的脂肪组织脂解一致。甘油数据还表明，冲刺1后脂肪分解的最初增加与IL-6无关。因此，脂肪组织中IL-6的增加可能补充其他短跑运动诱导的脂肪分解剂。这篇文章受版权保护。保留所有权利。
Enhanced interleukin-6 in human adipose tissue vein after sprint exercise: Results from a pilot study
Background
Low-volume sprint exercise is likely to reduce body fat. Interleukin (IL-6) may mediate this by increasing adipose tissue (AT) lipolysis. Therefore, the exchange of AT IL-6 and glycerol, a marker of lipolysis, was examined in 10 healthy subjects performing three 30-s all-out sprints.
Methods
Blood samples were obtained from brachial artery (a) and a superficial subcutaneous vein (v) on the anterior abdominal wall up to 9 min after the last sprint and analysed for IL-6 and glycerol.
Results
Arterial IL-6 increased 2-fold from rest to last sprint. AT venous IL-6 increased 15-fold from 0.4 ± 0.4 at rest to 7.0 ± 4 pg × mL−1 (p < 0.0001) and AT v–a difference increased 45-fold from 0.12 ± 0.3 to 6.0 ± 5 pg x mL−1 (p < 0.0001) 9 min after last sprint. Arterial glycerol increased 2.5-fold from rest to 9 min postsprint 1 (p < 0.0001) and was maintained during the exercise period. AT venous and v–a difference of glycerol increased 2-fold from rest to 9 min postsprint 1 (p < 0.0001 and p = 0.01, respectively), decreased until 18 min postsprint 2 (p < 0.001 and p < 0.0001), and then increased again until 9 min after last sprint (both p < 0.01).
Conclusions
The concurrent increase in venous IL-6 and glycerol in AT after last sprint is consistent with an IL-6 induced lipolysis in AT. Glycerol data also indicated an initial increase in lipolysis after sprint 1 that was unrelated to IL-6. Increased IL-6 in adipose tissue may, therefore, complement other sprint exercise-induced lipolytic agents.
期刊介绍：
Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest.
Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.
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