化疗诱发脱发的毛镜模式和共聚焦显微镜特征。

IF 1.4 Q3 DERMATOLOGY Skin Appendage Disorders Pub Date : 2023-10-01 Epub Date: 2023-07-12 DOI:10.1159/000531183
Maria Carmela Annunziata, Antonella Tosti, Davide Fattore, Luca Potestio, Austin John Maddy, Gabriella Fabbrocini
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引用次数: 0

摘要

简介:化疗性脱发(CIA)严重影响癌症患者的生活质量。CIA的毛状结构和共聚焦显微镜(RCM)特征研究较少。本研究旨在调查19名女性和5名男性CIA的皮肤镜和RCM特征,CIA是由当前或最近的化疗引起的。方法:选择有CIA和目前或最近(2个月内)化疗史的患者。临床检查后,用数码相机(SLR Canon PowerShot G10)拍摄标准照片,用Handyscope设备(20x)拍摄毛发镜图像。RCM的图像由VivaScope 3000使用VivaStack选项采集。三个独立的观察者在三个区域(顶点、中间和正面头皮)进行中心分割后获得了三角镜和共焦图像。结果:共有24名患者入选。毛镜下CIA具有生长期恶臭的特征,但黄点出现频率低,黑点突出。在毛发镜检查中同时存在假念珠和黑点,这证实了化疗间歇性损伤毛囊的假设。在RCM,异常发干形态的存在突出表明,损伤会影响发干的产生。结论:这些是该领域的第一批数据,因此需要对更多的患者进行进一步的研究来证实这些发现。
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Trichoscopic Patterns and Confocal Microscopy Features of Chemotherapy-Induced Alopecia.

Introduction: Chemotherapy-induced alopecia (CIA) can seriously affect the quality of life of cancer patients. Trichoscopic patterns and confocal microscopy (RCM) features of CIA have been scarcely studied. This study aimed to investigate the dermoscopic and RCM features of CIA in 19 females and 5 males, with CIA due to current or recent chemotherapy.

Methods: Patients with CIA and current or recent (within 2 months) history of chemotherapy treatment were enrolled. After clinical examination, standard pictures were taken by digital camera (SLR Canon PowerShot G10) and trichoscopic images were captured by the Handyscope device (20x). Images of RCM were acquired by VivaScope 3000 with the VivaStack option. The trichoscopic and confocal images were acquired by three independent observers after central parting on three areas: vertex, middle, and frontal scalp.

Results: A total of 24 patients were enrolled. CIA has features of anagen effluvium at trichoscopy but with low frequency of yellow dots and prominence of black dots. The simultaneous presence of pseudo-monilethrix and black dots at trichoscopy confirms the hypothesis that chemotherapy insults the hair follicle intermittently. At RCM, the presence of abnormal hair shaft morphology highlights that the insults affect hair shaft production.

Conclusion: These are the first data in this field, so further studies with a higher number of patients analyzed are needed to confirm these findings.

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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
69
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