[南美出血热病毒与疫苗和抗病毒药物开发的前沿]。

Uirusu Pub Date : 2022-01-01 DOI:10.2222/jsv.72.7

Meion Lee, Takaaki Koma, Masaharu Iwasaki, Shuzo Urata

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摘要

南美出血热是由Arenavirus引起的，该病毒属于Arenaviridae科，属于哺乳病毒属，在南美洲感染。南美出血热包括1。朱宁病毒引起的阿根廷出血热，2。Sabia病毒引起的巴西出血热，3。瓜纳里托病毒引起的委内瑞拉出血热，4。玻利维亚马丘波病毒引起的出血热，以及5。查帕雷病毒引起的未指定的出血热。根据系统发育、血清学和地理差异，这些病毒被归类为新世界（NW）Arenavirus，这与旧世界Arenavivirus（例如Lassa病毒）不同。在这篇综述中，将介绍引起南美洲出血热的NW Arenavirus的生物学知识以及疫苗和抗病毒药物的开发。

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[South American Hemorrhagic Fever viruses and the cutting edge of the vaccine and antiviral development].

South American Hemorrhagic Fever is caused by the Arenavirus, which belong to the Family Arenaviridae, genus mammarenavirus, infection at South America. South American Hemorrhagic Fever includes 1. Argentinian Hemorrhagic fever caused by Junin virus, 2. Brazilian hemorrhagic fever caused by Sabia virus, 3. Venezuelan Hemorrhagic fever caused by Guanarito virus, 4. Bolivian Hemorrhagic fever caused by Machupo virus, and 5. Unassigned hemorrhagic fever caused by Chapare virus. These viruses are classified in New World (NW) Arenavirus, which is different from Old World Arenavirus (ex. Lassa virus), based on phylogeny, serology, and geographic differences. In this review, the current knowledge of the biology and the development of the vaccines and antivirals of NW Arenaviruses which cause South American Hemorrhagic Fever will be described.

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