减轻HIV患者过早衰老的药理学和行为干预。

IF 3.7 2区 医学 Q2 INFECTIOUS DISEASES Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-02 DOI:10.1007/s11904-023-00677-7
Roxane Rohani, Jacob Malakismail, Emmanuel Njoku
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引用次数: 0

摘要

综述目的:我们试图综述已经公开提出、发表或目前正在进行的药物和行为干预措施,以预防或减轻过早HIV相关合并症的影响。最近的发现:已经进行了多项研究,希望找到一种有效的干预措施。虽然抗逆转录病毒疗法的选择会影响免疫功能的恢复,但一些用作辅助治疗的药物已被证明能有效缓解过早衰老。此外,很少有行为干预措施显示出一定的疗效。他汀类药物、血管紧张素受体阻滞剂、抗高血糖药物以及最佳依从性、运动和间歇性禁食等对免疫激活标志物和炎症生物标志物水平产生了有益影响。然而,几项调查没有得出结论,因此有必要对更大样本量进行进一步研究。
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Pharmacological and Behavioral Interventions to Mitigate Premature Aging in Patients with HIV.

Purpose of review: We sought to review pharmacological and behavioral interventions that have been publicly presented, published, or are currently ongoing to prevent or mitigate the effect of premature HIV-associated comorbidities.

Recent findings: Multiple studies have been conducted in hopes of finding an effective intervention. While the choice of antiretroviral regimen influences recovery of immune function, several drugs used as adjunct treatments have proven effective to mitigate premature aging. Additionally, few behavioral interventions have exhibited some efficacy. Statins, angiotensin-receptor blockers, and anti-hyperglycemic agents as well as optimal adherence, exercise, and intermittent fasting among others have had beneficial impact on markers of immune activation and levels of inflammatory biomarkers. However, several investigations had inconclusive outcomes so further studies with larger sample sizes are warranted.

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来源期刊
Current HIV/AIDS Reports
Current HIV/AIDS Reports INFECTIOUS DISEASES-
CiteScore
8.10
自引率
2.20%
发文量
45
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
期刊最新文献
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