父母的温暖、压力生活事件和冲动:一项全基因-环境交互研究。

IF 2.6 3区 心理学 Q3 NEUROSCIENCES Neuropsychology Pub Date : 2024-01-01 Epub Date: 2023-11-02 DOI:10.1037/neu0000927
Xinrui Wang, Hejun Liu, Qinghua He, Chuansheng Chen, Gui Xue, Qi Dong, Chunhui Chen
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引用次数: 0

摘要

目的:冲动受遗传、神经和环境因素的影响,但没有研究表明这些因素是如何共同作用产生冲动的个体差异的。本研究旨在定义服从冲动的功能网络,并测试其与基因-环境全交互研究中发现的基因-环境交互的关系。方法:本研究以健康的中国大学生(N=1145)为样本,确定基因-环境交互作用对冲动性的影响,然后在独立样本(N=483)中定义与冲动性相关的功能性脑网络,并利用多基因风险评分探讨基因-脑的关联。结果:本研究发现,14个基因与父母温暖(一种保护性环境因素)表现出显著的交互作用,6个基因与压力生活事件(一种风险环境因素)显示出显著的相互作用。父母温暖的多基因风险评分与功能连接显著相关,尤其是左额中回(MFG)-左枕下回和左MFG-左额上回功能连接,而压力较大的生活事件的多基因风险评分与左背内侧前额叶皮层(DMPFC)与其他区域的功能连接显著相关。在更不利的环境中(即父母温暖程度低或生活压力大),这些关联性更强。结论:这是第一次对冲动性进行全基因-环境交互研究。未来的研究应该复制我们的结果,并探索这些相互作用的潜在机制。(PsycInfo数据库记录(c)2023 APA,保留所有权利)。
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Parental warmth, stressful life events, and impulsivity: A gene-environment-wide interaction study.

Objective: Impulsivity is influenced by genetic, neural, and environmental factors, but no study has examined how these factors work together to generate individual differences in impulsivity. The present study aimed to define the functional network that subserves impulsivity and test its relations with the gene-environment interactions found in the gene-environment-wide interaction study.

Method: This study used a sample of healthy Chinese college students (N = 1,145) to identify gene-environment interactive effects on impulsivity, then defined the functional brain network related to impulsivity in an independent sample (N = 483), and explored the gene-brain associations using polygenic risk score.

Results: The present study found that 14 genes showed significant interactive effects with parental warmth (a protective environmental factor) and that six genes showed significant interactive effects with stressful life events (a risk environmental factor). The polygenic risk score for parental warmth was significantly correlated with functional connectivity especially the left middle frontal gyrus (MFG)-left inferior occipital and left MFG-left superior frontal gyrus functional connectivity, while the polygenic risk score for more stressful life events was significantly correlated with functional connectivity of left dorsal medial prefrontal cortex (DMPFC) to other regions. These associations were stronger in more adverse environments (i.e., low parental warmth or high stressful life events).

Conclusions: This was the first gene-environment-wide interaction study of impulsivity. Future studies should replicate our results and explore the underlying mechanisms of these interactions. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

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来源期刊
Neuropsychology
Neuropsychology 医学-神经科学
CiteScore
4.10
自引率
4.20%
发文量
132
审稿时长
6-12 weeks
期刊介绍: Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.
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