反复接触甲基苯丙胺可降低恒河猴血浆脑源性神经营养因子水平。

IF 5.3 3区医学 Q1 PSYCHIATRY General Psychiatry Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI:10.1136/gpsych-2023-101127

Wenlei Zhang, Jiahui Zhou, Hang Su, Xiaocheng Zhang, Weichen Song, Zijing Wang, Chengjie Tang, Kadir Uludağ, Min Zhao, Zhi-Qi Xiong, Rongwei Zhai, Haifeng Jiang

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引用次数: 0

摘要

背景：脑源性神经营养因子（BDNF）可预防甲基苯丙胺（METH）诱导的神经毒性，并在甲基苯丙胺成瘾的各个阶段发挥作用。然而，缺乏对活性METH依赖个体血浆BDNF水平变化的纵向设计研究。目的：本研究的目的是研究猴子在自行给药METH期间BDNF水平的变化。方法：本研究测定了三只持续暴露于甲基安非他明的雄性恒河猴和四只未暴露于甲基麻黄碱的雄性对照恒河猴的血浆BDNF水平。然后在三只猴子自我给药METH的40个疗程中纵向评估血浆BDNF水平的变化。结果：反复接触甲基安非他明可降低血浆BDNF水平。此外，在METH自我给药期间，血浆BDNF随着METH的长期而非短期积累而降低。结论：这些发现可能表明外周BDNF的变化可能反映了频繁用药期间累积的METH摄入量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys.

Background: Brain-derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)-induced neurotoxicity and plays a role in various stages of METH addiction. However, there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals.

Aims: The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys.

Methods: This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure. Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys.

Results: Repeated METH exposure decreased plasma BDNF levels. Additionally, plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration.

Conclusions: These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period.

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来源期刊

General Psychiatry 医学-精神病学

CiteScore

21.90

自引率

2.50%

发文量

848

期刊介绍： General Psychiatry (GPSYCH), an open-access journal established in 1959, has been a pioneer in disseminating leading psychiatry research. Addressing a global audience of psychiatrists and mental health professionals, the journal covers diverse topics and publishes original research, systematic reviews, meta-analyses, forums on topical issues, case reports, research methods in psychiatry, and a distinctive section on 'Biostatistics in Psychiatry'. The scope includes original articles on basic research, clinical research, community-based studies, and ecological studies, encompassing a broad spectrum of psychiatric interests.