反刍动物染色体进化模式。

IF 4.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Ecology Pub Date : 2023-11-08 DOI:10.1111/mec.17197
Cristina Arias-Sardá, Sarah Quigley, Marta Farré
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引用次数: 0

摘要

研究进化过程中基因组总重排发生的时间和地点是理解基因组结构变化的关键,其功能后果可能最终导致物种形成。在这里,我们鉴定了反刍动物的染色体重排,这是一个以大的染色体差异为特征的分支。利用26个基因组组装,我们重建了5个祖先核型,并对每个谱系中发生的重排事件进行了分类。通过这些重建,我们确定了进化断点区域(EBRs)和同基因片段。反刍动物的染色体组型进化以反转为特征,而染色体间重排优先发生在反刍动物最古老的祖先身上。我们发现EBRs缺乏蛋白质编码基因,包括持家基因。类似地,EBRs在高GC区域不富集,这表明减数分裂双链断裂可能不是它们的起源。总的来说,我们的研究结果详细描述了反刍动物进化中染色体重排的位置,并为EBRs的形成提供了新的见解。
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Patterns of chromosome evolution in ruminants.

Studying when and where gross genomic rearrangements occurred during evolution is key to understanding changes in genome structure with functional consequences that might eventually lead to speciation. Here we identified chromosome rearrangements in ruminants, a clade characterized by large chromosome differences. Using 26 genome assemblies, we reconstructed five ancestral karyotypes and classified the rearrangement events occurring in each lineage. With these reconstructions, we then identified evolutionary breakpoints regions (EBRs) and synteny fragments. Ruminant karyotype evolution is characterized by inversions, while interchromosomal rearrangements occurred preferentially in the oldest ancestor of ruminants. We found that EBRs are depleted of protein coding genes, including housekeeping genes. Similarly, EBRs are not enriched in high GC regions, suggesting that meiotic double strand breaks might not be their origin. Overall, our results characterize at fine detail the location of chromosome rearrangements in ruminant evolution and provide new insights into the formation of EBRs.

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来源期刊
Molecular Ecology
Molecular Ecology 生物-进化生物学
CiteScore
8.40
自引率
10.20%
发文量
472
审稿时长
1 months
期刊介绍: Molecular Ecology publishes papers that utilize molecular genetic techniques to address consequential questions in ecology, evolution, behaviour and conservation. Studies may employ neutral markers for inference about ecological and evolutionary processes or examine ecologically important genes and their products directly. We discourage papers that are primarily descriptive and are relevant only to the taxon being studied. Papers reporting on molecular marker development, molecular diagnostics, barcoding, or DNA taxonomy, or technical methods should be re-directed to our sister journal, Molecular Ecology Resources. Likewise, papers with a strongly applied focus should be submitted to Evolutionary Applications. Research areas of interest to Molecular Ecology include: * population structure and phylogeography * reproductive strategies * relatedness and kin selection * sex allocation * population genetic theory * analytical methods development * conservation genetics * speciation genetics * microbial biodiversity * evolutionary dynamics of QTLs * ecological interactions * molecular adaptation and environmental genomics * impact of genetically modified organisms
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