我国大面积小细胞肺癌癌症一线化疗加用塞普利单抗的成本效益。

IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2024-11-01 Epub Date: 2023-11-10 DOI:10.1080/14737167.2023.2281606
Shuo Kang, Huanlong Liu
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引用次数: 0

摘要

目的:本研究的目的是评估serplulimab联合化疗作为中国ES-SCLC患者一线策略的成本效益,与单独化疗相比。方法:采用基于中国医疗体系视角的决策分析模型,对两种竞争性一线治疗的经济效益进行评价。临床生存率和安全性数据来自ASTRUM-005试验,成本和效用值来自当地收费和先前发表的研究。成本和效用价值均按5%的年利率贴现。进行了敏感性分析和亚组分析,以检验模型结果的稳健性。结果:Serplulimab加化疗可以带来额外的0.25个QALY,边际成本为37569.32美元,导致每增加一个QALY的ICER为147908.74美元。敏感性分析证实,模型结果是稳健的。亚组分析显示,在一线化疗中加入serplulimab不太可能是所有亚组患者的成本效益高的选择。结论:与单独化疗相比,Serplulimab联合化疗不太可能是中国ES-SCLC患者的成本效益高的一线策略。降低serplulimab的价格可以提高其成本效益。
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Cost-effectiveness of adding serplulimab to first-line chemotherapy for extensive-stage small-cell lung cancer in China.

Objective: The aim of the current study was to evaluate the cost-effectiveness of serplulimab plus chemotherapy compared chemotherapy alone as first-line strategy for patients with ES-SCLC in China.

Methods: A decision-analytic model that based on the Chinese health-care system perspective was conducted to evaluate the economic benefits for the two competing first-line treatment. The clinical survival and safety data were obtained from the ASTRUM-005 trial, cost and utility values were gathered from the local charges and previously published study. Both cost and utility values were discounted at an annual rate of 5%. Sensitivity analyses and subgroup analyses were performed to examine the robustness of the model results.

Results: Serplulimab plus chemotherapy could bring additional 0.25 QALYs with the marginal cost of $37,569.32, resulting in an ICER of $147,908.74 per additional QALY gained. Sensitivity analyses confirmed that model results were robust. Subgroup analyses revealed that adding serplulimab to first-line chemotherapy were unlikely to be the cost-effective option for all subgroup patients.

Conclusions: Serplulimab plus chemotherapy was unlikely to be the cost-effective first-line strategy compared with chemotherapy alone for patients with ES-SCLC in China. Reduced the price of serplulimab could increase its cost-effective.

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来源期刊
Expert Review of Pharmacoeconomics & Outcomes Research
Expert Review of Pharmacoeconomics & Outcomes Research HEALTH CARE SCIENCES & SERVICES-PHARMACOLOGY & PHARMACY
CiteScore
4.00
自引率
4.30%
发文量
68
审稿时长
6-12 weeks
期刊介绍: Expert Review of Pharmacoeconomics & Outcomes Research (ISSN 1473-7167) provides expert reviews on cost-benefit and pharmacoeconomic issues relating to the clinical use of drugs and therapeutic approaches. Coverage includes pharmacoeconomics and quality-of-life research, therapeutic outcomes, evidence-based medicine and cost-benefit research. All articles are subject to rigorous peer-review. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.
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