高蛋白、增加纤维、补充ω-3脂肪酸的干燥饮食对接受化疗的狗的生活质量的影响。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary and comparative oncology Pub Date : 2024-03-01 Epub Date: 2023-11-07 DOI:10.1111/vco.12940
Cailin R Heinze, Kristine E Burgess, Lisa G Barber, Kenneth M Rassnick, Gerald S Post, Richard Segaloff, Julie Bayle
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引用次数: 0

摘要

癌症狗的生活质量(QOL)是评估癌症治疗方案的关键考虑因素。尽管人们对改善肿瘤患者管理的饮食策略感兴趣,但很少有临床研究表明饮食对狗化疗不良反应的影响。这项研究是一项随机、对照、双盲、多中心临床试验,旨在为接受标准护理化疗的癌症狗研究补充ω-3脂肪酸的高蛋白、高纤维饮食。患有新诊断的2级或更高级别肥大细胞肿瘤(或不可切除/不完全切除的肿瘤)或多中心淋巴瘤的客户饲养的狗被随机分配接受试验饮食(n = 24)或对照饮食(n = 21)用于8 周。主要结果是生活质量评估、粪便评分以及血液中C反应蛋白和单核细胞趋化蛋白-1的浓度。在12个生活质量参数中,与对照组的1个相比,试验组的10个从基线到第8周显著改善。然而,两组之间的差异仅在“疾病迹象的频率”方面具有统计学意义(P = .009)。两组之间任何不良事件(包括胃肠道不良事件)的发生率均无显著差异,实验室参数或粪便评分也无临床显著差异。没有观察到试验饮食的负面影响,再加上与饮食相关的生活质量改善幅度,表明有必要进行更大规模的试验。
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Effects of a high-protein, increased-fibre, dry diet supplemented with omega-3 fatty acids on quality of life in dogs undergoing chemotherapy.

Quality of life (QOL) in dogs with cancer is a key consideration in the assessment of cancer treatment options. Despite interest in dietary strategies to improve management of oncology patients, there have been very few clinical studies showing the impact of diet on adverse effects of chemotherapy in dogs. This study was a randomised, controlled, double-blinded, multicenter clinical trial to investigate a high-protein, increased-fibre diet supplemented with omega-3 fatty acids, for dogs with cancer undergoing standard-of-care chemotherapy. Client-owned dogs with newly diagnosed grade 2 or higher mast cell tumours (or non-resectable/incompletely resected tumours) or multicentric lymphoma were randomised to receive the test diet (n = 24) or control diet (n = 21) for 8 weeks. Primary outcomes were QOL assessments, faecal scores, and blood concentrations of C-reactive protein and monocyte chemoattractant protein-1. Of 12 QOL parameters, 10 significantly improved from baseline to Week 8 in the test group compared with one in the control group. However, differences between the two groups were only statistically significant for 'frequency of signs of illness' (P = .009). There were no significant differences in the incidence of any adverse events, including gastrointestinal adverse events or clinically significant differences in laboratory parameters or faecal scores between the two groups. The absence of an observed negative impact of the test diet, combined with the magnitude of QOL improvements associated with the diet, suggest that a larger trial is warranted.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
期刊最新文献
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