从千叶Stephania cepharantha块根中提取的吗啡和异喹啉生物碱。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-02-01 DOI:10.1080/14786419.2023.2275740

Haoran Ma , Xiaoqi Jin , Fuqian Wang , Jie Jiang , Lu Cheng , Song Hu , Geng Zhang , Hongfeng Xu

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引用次数: 0

摘要

一种新的吗啡喃生物碱（6S，9S，13 R、 14S）-6-O-乙酰基-7,8-二氢-4-羟基-3,7-二甲氧基吗啡喃-6-醇（1）和一种新的天然轮藻碱（S）-2，3，12，12a-四氢-5，6，9，10-四甲氧基-1-甲基-1H-[1]苯并xepino[2，3，4-ij]异喹啉（5），以及四种已知的生物碱。基于光谱数据分析，阐明了这些化合物的结构。还评估了化合物对三种人癌症细胞系（A549、MCF-7和SW480）的细胞毒性活性。

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Morphinan and isoquinoline alkaloids from the tuberous roots of Stephania cepharantha

A new morphinan alkaloid (6S, 9S, 13 R, 14S)-6-O-acetyl-7,8-Didehydro-4-hydroxy-3,7-dimethoxymorphinan-6-ol (1), and a new naturally occurring cularine alkaloid (S)-2, 3, 12, 12a-tetrahydro-5, 6, 9, 10-tetramethoxy-1-methyl-1H-[1]benzoxepino[2, 3, 4-ij]isoquinoline(5), along with four known alkaloids were isolated from the roots of Stephania cepharantha. The structures of these compounds were elucidated based on spectroscopic data analyses. Cytotoxic activities of the compounds against three human cancer cell lines (A549, MCF-7 and SW480) were also evaluated.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.