Nishith Ghosh*, Pallavee Vitti Krushna, Jagdish D. Sharma and Alok Srivastava,
{"title":"涂料行业相关化学品皮肤吸收电位的评价","authors":"Nishith Ghosh*, Pallavee Vitti Krushna, Jagdish D. Sharma and Alok Srivastava, ","doi":"10.1021/acs.chas.3c00026","DOIUrl":null,"url":null,"abstract":"<p >Painters experience occupational exposure through inhalation and skin absorption to various chemicals that are used as ingredients of paint mixtures and other related painting trades. Although several investigations indicated significant contribution of exposure via skin absorption to exhibit harmful effects on health among painters, assessment of the skin absorption hazards of the paint chemicals is limited. Here, we evaluated the skin absorption of a number of organic chemicals relevant to painting trades using mathematical models. For this purpose, we estimated the skin permeability coefficient of the chemicals using the Potts and Guy correlation equation. The estimated permeability coefficients were further utilized to estimate the maximum flux of the non-volatile chemicals across the skin. The skin permeability coefficient and maximum flux of the chemicals across the skin were compared to those of the chemicals to which the American Conference of Governmental Industrial Hygienists (ACGIH) assigned a “skin” notation. We critically analyzed the estimated maximum fluxes and the acute toxicity data of the chemicals available in the literature that helped to identify the chemicals posing a significant skin absorption hazard. The analyses suggest that triethanolamine and <i>m</i>-phenylenediamine pose significant skin absorption hazards, though these chemicals have not yet been assigned a “skin” notation in the ACGIH TLV book. The ratio of dermal uptake directly from air to inhalation intake of volatile solvents used in paint mixtures was estimated for a typical occupational setting. <i>N</i>-Methyl-2-pyrrolidone showed significant dermal uptake fraction compared to its intake via inhalation route.</p>","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Skin Absorption Potential of Chemicals Relevant to Painting Trades\",\"authors\":\"Nishith Ghosh*, Pallavee Vitti Krushna, Jagdish D. Sharma and Alok Srivastava, \",\"doi\":\"10.1021/acs.chas.3c00026\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Painters experience occupational exposure through inhalation and skin absorption to various chemicals that are used as ingredients of paint mixtures and other related painting trades. Although several investigations indicated significant contribution of exposure via skin absorption to exhibit harmful effects on health among painters, assessment of the skin absorption hazards of the paint chemicals is limited. Here, we evaluated the skin absorption of a number of organic chemicals relevant to painting trades using mathematical models. For this purpose, we estimated the skin permeability coefficient of the chemicals using the Potts and Guy correlation equation. The estimated permeability coefficients were further utilized to estimate the maximum flux of the non-volatile chemicals across the skin. The skin permeability coefficient and maximum flux of the chemicals across the skin were compared to those of the chemicals to which the American Conference of Governmental Industrial Hygienists (ACGIH) assigned a “skin” notation. We critically analyzed the estimated maximum fluxes and the acute toxicity data of the chemicals available in the literature that helped to identify the chemicals posing a significant skin absorption hazard. The analyses suggest that triethanolamine and <i>m</i>-phenylenediamine pose significant skin absorption hazards, though these chemicals have not yet been assigned a “skin” notation in the ACGIH TLV book. The ratio of dermal uptake directly from air to inhalation intake of volatile solvents used in paint mixtures was estimated for a typical occupational setting. <i>N</i>-Methyl-2-pyrrolidone showed significant dermal uptake fraction compared to its intake via inhalation route.</p>\",\"PeriodicalId\":12,\"journal\":{\"name\":\"ACS Chemical Health & Safety\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2023-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Chemical Health & Safety\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.chas.3c00026\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Chemical Health & Safety","FirstCategoryId":"1","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.chas.3c00026","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Evaluation of Skin Absorption Potential of Chemicals Relevant to Painting Trades
Painters experience occupational exposure through inhalation and skin absorption to various chemicals that are used as ingredients of paint mixtures and other related painting trades. Although several investigations indicated significant contribution of exposure via skin absorption to exhibit harmful effects on health among painters, assessment of the skin absorption hazards of the paint chemicals is limited. Here, we evaluated the skin absorption of a number of organic chemicals relevant to painting trades using mathematical models. For this purpose, we estimated the skin permeability coefficient of the chemicals using the Potts and Guy correlation equation. The estimated permeability coefficients were further utilized to estimate the maximum flux of the non-volatile chemicals across the skin. The skin permeability coefficient and maximum flux of the chemicals across the skin were compared to those of the chemicals to which the American Conference of Governmental Industrial Hygienists (ACGIH) assigned a “skin” notation. We critically analyzed the estimated maximum fluxes and the acute toxicity data of the chemicals available in the literature that helped to identify the chemicals posing a significant skin absorption hazard. The analyses suggest that triethanolamine and m-phenylenediamine pose significant skin absorption hazards, though these chemicals have not yet been assigned a “skin” notation in the ACGIH TLV book. The ratio of dermal uptake directly from air to inhalation intake of volatile solvents used in paint mixtures was estimated for a typical occupational setting. N-Methyl-2-pyrrolidone showed significant dermal uptake fraction compared to its intake via inhalation route.
期刊介绍:
The Journal of Chemical Health and Safety focuses on news, information, and ideas relating to issues and advances in chemical health and safety. The Journal of Chemical Health and Safety covers up-to-the minute, in-depth views of safety issues ranging from OSHA and EPA regulations to the safe handling of hazardous waste, from the latest innovations in effective chemical hygiene practices to the courts'' most recent rulings on safety-related lawsuits. The Journal of Chemical Health and Safety presents real-world information that health, safety and environmental professionals and others responsible for the safety of their workplaces can put to use right away, identifying potential and developing safety concerns before they do real harm.