老年妇女患乳腺癌的危险因素与年轻的绝经后妇女相似

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摘要

问题已知的危险因素对75岁以上女性乳腺癌症发病率有什么影响?研究设计前瞻性队列研究。主要结果75岁以上女性BMI和身高的增加与患癌症的风险增加相关。在这一组中,尽管五次或五次以上的活产降低了患癌症的风险,但无效并不是一个危险因素。绝经年龄越大,风险越高(见结果表)。作者的结论在75–84岁的女性中,BMI增加、有癌症家族史和绝经年龄越长,患癌症的风险越高,而五个以上的活产是一个保护因素。这些风险因素与年轻绝经后妇女的风险因素相似。
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Risk factors for breast cancer in elderly women are similar to those for younger post-menopausal women

Question

What influence do known risk factors have on incidence of breast cancer in women over 75 years old?

Study design

Prospective cohort study.

Main results

Increases in BMI and height were associated with increasing risk of breast cancer among women over 75. Nulliparity was not a risk factor in this group, although five or more previous live births reduced risk of breast cancer. Older age at menopause increased risk (see results table).

Authors’ conclusions

In women aged 75–84 years, increasing BMI, a family history of breast cancer and older age at menopause increased risk of incident breast cancer while more than five live births was a protective factor. These risk factors are similar to those for younger post-menopausal women.

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