Y-STR单倍型频率估计的离散拉普拉斯方法的实验推广

IF 0.5 Q4 GENETICS & HEREDITY Forensic Science International: Genetics Supplement Series Pub Date : 2022-12-01 DOI:10.1016/j.fsigss.2022.10.047

Maarten Kruijver , Duncan Taylor , John Buckleton

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引用次数: 0

摘要

Y-STR单倍型的频率估计是一个具有挑战性的问题，因为可用的数据有限，并且数据中存在复杂的依赖性。结果，已经提出了用于频率估计的各种统计方法。离散拉普拉斯方法已被ISFG的DNA委员会在某些情况下推荐。这种方法仅限于在所有基因座上具有单一整数重复等位基因的单倍型。我们提出了一种处理重复基因座（如DYS385）和非整数重复的不太常见等位基因的方法的推广。该扩展是在一个名为disclapmix2的实验R包中实现的。

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An experimental extension to the discrete Laplace method for Y-STR haplotype frequency estimation

Frequency estimation for Y-STR haplotypes is a challenging problem because limited data are available and complex dependencies exist within the data. As a result, various statistical methods have been proposed for frequency estimation. The discrete Laplace method has been recommended in some contexts by the DNA commission of the ISFG. This method is limited to haplotypes with single integer repeat alleles only at all loci. We propose a generalisation of the method that handles duplicated loci such as DYS385 and less common alleles that are not integer repeats. The extension is implemented in an experimental R package called disclapmix2.

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来源期刊

Forensic Science International: Genetics Supplement Series Medicine-Pathology and Forensic Medicine

CiteScore

0.40

自引率

0.00%

发文量

122

审稿时长

25 days

期刊介绍： The Journal of Forensic Science International Genetics Supplement Series is the perfect publication vehicle for the proceedings of a scientific symposium, commissioned thematic issues, or for disseminating a selection of invited articles. The Forensic Science International Genetics Supplement Series is part of a duo of publications on forensic genetics, published by Elsevier on behalf of the International Society for Forensic Genetics.