{"title":"1,2-萘醌衍生物、希夫碱络合物以及与 8-羟基喹啉的三元络合物的合成与结构解析：其抗菌、抗炎和抗糖尿病活性的比较研究","authors":"Seema, Shobhana Sharma, Poonam Yadav, Suman Kumari, Mamta Ranka","doi":"10.1007/s11243-023-00551-w","DOIUrl":null,"url":null,"abstract":"<div><p>Herein, a new derivative of 1,2-naphthoquinone with semicarbazide and its Schiff base complexes and ternary complexes have been synthesized with some transition metals such as Ni(II), Co(II) and Zn(II) by using the conventional reflux method and 8-hydroxyquinoline (8-HQ) as a secondary ligand for ternary complexes. All the compounds were characterized using elemental analysis, molar conductance, melting point, Powder XRD, magnetic moment measurement and various spectral techniques such as FTIR, <sup>13</sup>C NMR, <sup>1</sup>H NMR, and Mass Spectra. The specific peak of the enolic proton in <sup>1</sup>H NMR spectra of the tridentate ligand (L) explained the amido-iminol tautomerism in semicarbazone. In addition, powder XRD analysis and TGA confirmed the crystalline nature and the thermal study of metal chelates, respectively<i>. </i>In vitro<i>,</i> all the compounds were screened for antimicrobial (against bacterial strains: <i>S. aureus</i> and <i>E. coli</i>; Fungal strain: <i>A. niger</i>), anti-diabetic and anti-inflammatory activity with their obtained IC<sub>50</sub> values and compared with Acarbose and Aspirin standard drugs. Bioactivities of azomethine containing free ligand (L), their Schiff base complexes and ternary metal chelates were compared to each other. Free Schiff base (L) was found most potent for all selective bioactivities compared to their all-metal complexes, except Ni (II) Schiff base complex showed excellent activity against <i>C. albicans.</i></p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"48 6","pages":"389 - 400"},"PeriodicalIF":1.6000,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and structural elucidation of 1,2-naphthoquinone derivatives, Schiff base complexes and ternary complexes with 8-hydroxyquinoline: comparative studies of their antimicrobial, anti-inflammatory and anti-diabetic activities\",\"authors\":\"Seema, Shobhana Sharma, Poonam Yadav, Suman Kumari, Mamta Ranka\",\"doi\":\"10.1007/s11243-023-00551-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Herein, a new derivative of 1,2-naphthoquinone with semicarbazide and its Schiff base complexes and ternary complexes have been synthesized with some transition metals such as Ni(II), Co(II) and Zn(II) by using the conventional reflux method and 8-hydroxyquinoline (8-HQ) as a secondary ligand for ternary complexes. All the compounds were characterized using elemental analysis, molar conductance, melting point, Powder XRD, magnetic moment measurement and various spectral techniques such as FTIR, <sup>13</sup>C NMR, <sup>1</sup>H NMR, and Mass Spectra. The specific peak of the enolic proton in <sup>1</sup>H NMR spectra of the tridentate ligand (L) explained the amido-iminol tautomerism in semicarbazone. In addition, powder XRD analysis and TGA confirmed the crystalline nature and the thermal study of metal chelates, respectively<i>. </i>In vitro<i>,</i> all the compounds were screened for antimicrobial (against bacterial strains: <i>S. aureus</i> and <i>E. coli</i>; Fungal strain: <i>A. niger</i>), anti-diabetic and anti-inflammatory activity with their obtained IC<sub>50</sub> values and compared with Acarbose and Aspirin standard drugs. Bioactivities of azomethine containing free ligand (L), their Schiff base complexes and ternary metal chelates were compared to each other. Free Schiff base (L) was found most potent for all selective bioactivities compared to their all-metal complexes, except Ni (II) Schiff base complex showed excellent activity against <i>C. albicans.</i></p></div>\",\"PeriodicalId\":803,\"journal\":{\"name\":\"Transition Metal Chemistry\",\"volume\":\"48 6\",\"pages\":\"389 - 400\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2023-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transition Metal Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11243-023-00551-w\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transition Metal Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11243-023-00551-w","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Synthesis and structural elucidation of 1,2-naphthoquinone derivatives, Schiff base complexes and ternary complexes with 8-hydroxyquinoline: comparative studies of their antimicrobial, anti-inflammatory and anti-diabetic activities
Herein, a new derivative of 1,2-naphthoquinone with semicarbazide and its Schiff base complexes and ternary complexes have been synthesized with some transition metals such as Ni(II), Co(II) and Zn(II) by using the conventional reflux method and 8-hydroxyquinoline (8-HQ) as a secondary ligand for ternary complexes. All the compounds were characterized using elemental analysis, molar conductance, melting point, Powder XRD, magnetic moment measurement and various spectral techniques such as FTIR, 13C NMR, 1H NMR, and Mass Spectra. The specific peak of the enolic proton in 1H NMR spectra of the tridentate ligand (L) explained the amido-iminol tautomerism in semicarbazone. In addition, powder XRD analysis and TGA confirmed the crystalline nature and the thermal study of metal chelates, respectively. In vitro, all the compounds were screened for antimicrobial (against bacterial strains: S. aureus and E. coli; Fungal strain: A. niger), anti-diabetic and anti-inflammatory activity with their obtained IC50 values and compared with Acarbose and Aspirin standard drugs. Bioactivities of azomethine containing free ligand (L), their Schiff base complexes and ternary metal chelates were compared to each other. Free Schiff base (L) was found most potent for all selective bioactivities compared to their all-metal complexes, except Ni (II) Schiff base complex showed excellent activity against C. albicans.
期刊介绍：
Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc.
Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.
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