Patricia San José, Mireia Guerrero, Isabel García-Martín, Jordi Caballero, Manuel Pérez-Maraver
{"title":"2003-2010年非高加索人群因糖尿病入院的影响和特点","authors":"Patricia San José, Mireia Guerrero, Isabel García-Martín, Jordi Caballero, Manuel Pérez-Maraver","doi":"10.1016/j.endoen.2016.06.009","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><p>To assess the prevalence of non-Caucasian patients in hospital admissions for onset of symptomatic diabetes mellitus during the 2003–2010 period, and to analyze the characteristics differentiating them from the Caucasian population at diagnosis and 2 years later.</p></div><div><h3>Material and methods</h3><p>A retrospective, observational study. Inclusion criteria: patients aged 18–40 years admitted for de novo symptomatic diabetes from January 2003 to October 2010. Prevalence of patients of non-Caucasian origin was analyzed, and clinical, biochemical, immunological, and beta-cell function of both populations were compared at diagnosis and 2 years later.</p></div><div><h3>Results</h3><p>Nineteen percent of patients admitted to hospital for de novo symptomatic diabetes were non-Caucasian, with a progressive increase in recent years. Non-Caucasian patients had milder decompensation (3.0% had ketoacidosis, as compared to 15.2% in the Caucasian group, <em>p</em> <!--><<!--> <!-->0.05), lower presence of autoimmunity (27.2 vs. 73.1%, <em>p</em> <!--><<!--> <!-->0.01) and higher stimulated C-peptide levels (0.70<!--> <!-->±<!--> <!-->0.56 vs. 0.42<!--> <!-->±<!--> <!-->0.39<!--> <!-->nmol/L, <em>p</em> <!--><<!--> <!-->0.05), mainly because of the subgroup with negative autoimmunity (0.82 vs. 0.25). Two years after diagnosis, less non-Caucasian patients were on intensified treatment (39.1 vs. 93.8%).</p></div><div><h3>Conclusions</h3><p>Non-Caucasian patients had a lower prevalence of autoimmunity, better beta-cell function at diagnosis, particularly due to the subgroup with negative autoimmunity, and less need for intensive treatment 2 years after diagnosis, features which are more characteristic of type 2 diabetes mellitus.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 6","pages":"Pages 285-290"},"PeriodicalIF":0.0000,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.06.009","citationCount":"0","resultStr":"{\"title\":\"Impact and characteristics of the non-Caucasian population in hospital admissions for diabetes onset during 2003–2010\",\"authors\":\"Patricia San José, Mireia Guerrero, Isabel García-Martín, Jordi Caballero, Manuel Pérez-Maraver\",\"doi\":\"10.1016/j.endoen.2016.06.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aims</h3><p>To assess the prevalence of non-Caucasian patients in hospital admissions for onset of symptomatic diabetes mellitus during the 2003–2010 period, and to analyze the characteristics differentiating them from the Caucasian population at diagnosis and 2 years later.</p></div><div><h3>Material and methods</h3><p>A retrospective, observational study. Inclusion criteria: patients aged 18–40 years admitted for de novo symptomatic diabetes from January 2003 to October 2010. Prevalence of patients of non-Caucasian origin was analyzed, and clinical, biochemical, immunological, and beta-cell function of both populations were compared at diagnosis and 2 years later.</p></div><div><h3>Results</h3><p>Nineteen percent of patients admitted to hospital for de novo symptomatic diabetes were non-Caucasian, with a progressive increase in recent years. Non-Caucasian patients had milder decompensation (3.0% had ketoacidosis, as compared to 15.2% in the Caucasian group, <em>p</em> <!--><<!--> <!-->0.05), lower presence of autoimmunity (27.2 vs. 73.1%, <em>p</em> <!--><<!--> <!-->0.01) and higher stimulated C-peptide levels (0.70<!--> <!-->±<!--> <!-->0.56 vs. 0.42<!--> <!-->±<!--> <!-->0.39<!--> <!-->nmol/L, <em>p</em> <!--><<!--> <!-->0.05), mainly because of the subgroup with negative autoimmunity (0.82 vs. 0.25). Two years after diagnosis, less non-Caucasian patients were on intensified treatment (39.1 vs. 93.8%).</p></div><div><h3>Conclusions</h3><p>Non-Caucasian patients had a lower prevalence of autoimmunity, better beta-cell function at diagnosis, particularly due to the subgroup with negative autoimmunity, and less need for intensive treatment 2 years after diagnosis, features which are more characteristic of type 2 diabetes mellitus.</p></div>\",\"PeriodicalId\":48670,\"journal\":{\"name\":\"Endocrinologia Y Nutricion\",\"volume\":\"63 6\",\"pages\":\"Pages 285-290\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.endoen.2016.06.009\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrinologia Y Nutricion\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2173509316300526\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinologia Y Nutricion","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2173509316300526","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Impact and characteristics of the non-Caucasian population in hospital admissions for diabetes onset during 2003–2010
Aims
To assess the prevalence of non-Caucasian patients in hospital admissions for onset of symptomatic diabetes mellitus during the 2003–2010 period, and to analyze the characteristics differentiating them from the Caucasian population at diagnosis and 2 years later.
Material and methods
A retrospective, observational study. Inclusion criteria: patients aged 18–40 years admitted for de novo symptomatic diabetes from January 2003 to October 2010. Prevalence of patients of non-Caucasian origin was analyzed, and clinical, biochemical, immunological, and beta-cell function of both populations were compared at diagnosis and 2 years later.
Results
Nineteen percent of patients admitted to hospital for de novo symptomatic diabetes were non-Caucasian, with a progressive increase in recent years. Non-Caucasian patients had milder decompensation (3.0% had ketoacidosis, as compared to 15.2% in the Caucasian group, p < 0.05), lower presence of autoimmunity (27.2 vs. 73.1%, p < 0.01) and higher stimulated C-peptide levels (0.70 ± 0.56 vs. 0.42 ± 0.39 nmol/L, p < 0.05), mainly because of the subgroup with negative autoimmunity (0.82 vs. 0.25). Two years after diagnosis, less non-Caucasian patients were on intensified treatment (39.1 vs. 93.8%).
Conclusions
Non-Caucasian patients had a lower prevalence of autoimmunity, better beta-cell function at diagnosis, particularly due to the subgroup with negative autoimmunity, and less need for intensive treatment 2 years after diagnosis, features which are more characteristic of type 2 diabetes mellitus.