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Endocrinology, diabetes and nutrition: The future is here 内分泌、糖尿病和营养:未来就在这里
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.10.014
Dídac Mauricio , Ignacio Conget , Edelmiro Menéndez , Manuel Puig-Domingo
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引用次数: 0
Venlafaxine drug interaction in the diagnosis of pheochromocytoma 文拉法辛药物相互作用在嗜铬细胞瘤诊断中的应用
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.08.014
Ana Belén Mañas-Martínez, Alicia Aragoneses-Calvo, Ana Matei, Sylvie Ojeda-Rodríguez, Pilar García-Durruti
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引用次数: 0
Use of healthcare resources and costs associated to the start of treatment with injectable drugs in patients with type 2 diabetes mellitus 2型糖尿病患者开始注射药物治疗的医疗资源使用和相关费用
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.07.002
Antoni Sicras-Mainar , Ruth Navarro-Artieda , Raúl Morano , Lucía Ruíz

Objectives

The main objective was to assess resource use and costs of starting treatment with insulin or injectable GLP-1 receptor analogs (GLP-1 RAs) in a Spanish population of patients with type 2 diabetes mellitus. Treatment adherence and persistence were also determined for both treatment groups.

Patients and methods

A retrospective, non-interventional, observational study was conducted. Patients aged ≥20 years who started treatment with insulin or GLP-1 RAs in the 2010–2012 period were recruited. Use of healthcare resources was estimated to evaluate healthcare costs in these two groups of patients (medical visits, hospital stay, emergency visits, diagnostic or treatment requests, medication). Clinical information including body mass index (BMI, kg/m2), metabolic control (HbA1c), adherence, persistence, and complications hypoglycemia, and cardiovascular events (CVE) was collected. The follow-up period was 12 months. Only direct healthcare costs were considered.

Results

A total of 1301 patients with a mean age of 67.6 years (51.6% males) were recruited. Of these, 71.9% and 28.1% were on treatment with insulin and GLP-1 RA respectively. After one year of follow-up, patients treated with GLP-1 RAs were found less visits to primary care (8 vs. 11; p < 0.001) and specialized care (1.0 vs. 1.8; p < 0.001), hospital stays (0.3 vs. 0.7; p = 0.030) and less visits to the emergency room (0.8 vs. 1.6; p < 0.001). Patients treated with GLP-1 showed greater adherence (88.1% vs. 82.7%; p < 0.001) and persistence (62.0% vs. 55.9%; p = 0.046), and had less hypoglycemia episodes (13.4% vs. 18.7%; p = 0.022), with similar metabolic control (HbA1c: 7.2% vs. 7.4%; p = 0.049), BMI (29.1 vs. 30.9 kg/m2), and CVE rate (9.1% vs. 11.5%; p = 0.330) respectively. The mean corrected direct healthcare cost per patient was €1787 vs. €2005 (p = 0.046.)

Conclusions

Patients treated with GLP-1 RAs caused lower direct healthcare costs for the National Health System than patients treated with insulin. The results may be explained by greater treatment adherence and lower hypoglycemia rates in patients treated with GLP-1 RAs. Additional studies are needed to confirm these possibilities.

目的主要目的是评估西班牙2型糖尿病患者开始使用胰岛素或注射型GLP-1受体类似物(GLP-1 RA)治疗的资源使用和成本。还确定了两个治疗组的治疗依从性和持续性。患者和方法进行回顾性、非介入性、观察性研究。招募年龄≥20岁的患者,这些患者在2010-2012年期间开始接受胰岛素或GLP-1 RA治疗。估计了医疗资源的使用情况,以评估这两组患者的医疗成本(就诊、住院、急诊、诊断或治疗请求、药物)。收集包括体重指数(BMI,kg/m2)、代谢控制(HbA1c)、依从性、持续性和并发症低血糖以及心血管事件(CVE)在内的临床信息。随访12个月。只考虑了直接的医疗费用。结果共招募1301名患者,平均年龄67.6岁(51.6%为男性)。其中,71.9%和28.1%分别接受胰岛素和GLP-1 RA治疗。在一年的随访后,发现接受GLP-1 RA治疗的患者较少去初级护理(8对11;p<0.001)和专科护理(1.0对1.8;p<001),住院时间(0.3 vs.0.7;p=0.030)和急诊室就诊次数较少(0.8 vs.1.6;p<0.001)。接受GLP-1治疗的患者表现出更高的依从性(88.1%vs.82.7%;p<001)和持久性(62.0%vs.55.9%;p=0.046),低血糖发作次数较少(13.4%vs.18.7%;p=0.022),代谢控制相似(HbA1c:7.2%vs.7.4%;p<0.049),BMI(29.1 vs.30.9 kg/m2)和CVE率(9.1%vs.11.5%;p=0.330)。每位患者的平均校正直接医疗费用为1787欧元,而2005欧元(p=0.046)。结论接受GLP-1 RA治疗的患者比接受胰岛素治疗的患者在国家卫生系统中造成的直接医疗费用更低。这一结果可以通过GLP-1 RA治疗的患者更高的治疗依从性和更低的低血糖率来解释。还需要进一步的研究来证实这些可能性。
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引用次数: 3
Efficacy and safety of empagliflozin in combination with other oral hypoglycemic agents in patients with type 2 diabetes mellitus 恩帕列嗪联合其他口服降糖药治疗2型糖尿病的疗效和安全性
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.11.001
Irene Romera , Francisco Javier Ampudia-Blasco , Antonio Pérez , Bernat Ariño , Egon Pfarr , Sanja Giljanovic Kis , Ebrahim Naderali

Introduction

To analyze the efficacy and safety of empagliflozin combined with other oral hypoglycemic agents in patients with type 2 diabetes mellitus.

Methods

Pooled analysis of three phase III trials in patients with type 2 diabetes mellitus (n = 1801) who received placebo or empagliflozin 10 or 25 mg once daily for 24 weeks, in combination with metformin, metformin + sulphonylurea or pioglitazone ± metformin.

Results

Empagliflozin significantly decreased HbA1c (adjusted mean reduction vs placebo with empagliflozin 10 mg: −0.58% [95% CI: −0.66; −0.49]; p < 0.0001, and with empagliflozin 25 mg: −0.62% [95% CI: −0.70; −0.53], p < 0.0001), weight (adjusted mean reduction vs placebo with empagliflozin 10 mg: −1.77 kg [95% CI: −2.05; −1.48]; p < 0.0001, and with empagliflozin 25 mg: −1.96 kg [95% CI: −2.24; −1.67], p < 0.0001), and systolic and diastolic blood pressure (SBP/DBP). Adverse effect rates were 64% with placebo, 63.9% with empagliflozin 10 mg, and 60.9% with empagliflozin 25 mg. Documented episodes of hypoglycemia (≤70 mg/dL and/or requiring care) occurred in 3.9% of patients with placebo, 6.9% of patients with empagliflozin 10 mg, and 5.3% of patients with empagliflozin 25 mg. Urinary tract infections developed in 9.4% of patients with placebo, 10.2% of patients with empagliflozin 10 mg, and 8.3% of patients with empagliflozin 25 mg. Genital infections were reported in 1.0% of patients with placebo, 4.6% of patients with empagliflozin 10 mg, and 3.5% of patients with empagliflozin 25 mg.

Conclusions

Empagliflozin combined with other oral treatments decreased HbA1c, body weight, and SBP/DBP as compared to placebo, with a good safety and tolerability profile.

前言:分析恩帕列嗪联合其他口服降糖药治疗2型糖尿病的疗效和安全性。方法对2型糖尿病患者(n=1801)的三项III期试验进行汇总分析,这些患者接受安慰剂或恩帕列嗪10或25mg,每日一次,持续24周,联合二甲双胍,二甲双胍+磺脲或吡格列酮±二甲双胍。结果恩帕格列嗪显著降低HbA1c(恩帕格列嗪10 mg组与安慰剂组相比,调整后的平均降低率为−0.58%[95%CI:−0.66;−0.49];p<;0.0001,恩帕格列嗪25 mg组为−0.62%[95%CI:−0.70;−0.53],p<),体重(与安慰剂相比,恩帕列嗪10 mg的调整后平均减少量:−1.77 kg[95%CI:−2.05;−1.48];p<;0.0001,恩帕列嗪25 mg:−1.96 kg[95%CI:−2.24;−1.67],p<:0.0001),以及收缩压和舒张压(SBP/DBP)。安慰剂组的不良反应发生率为64%,恩帕格列嗪10 mg组为63.9%,恩帕格列嗪25 mg组为60.9%。3.9%的安慰剂患者、6.9%的恩帕格列嗪10 mg患者和5.3%的恩帕列嗪25 mg患者发生了记录在案的低血糖发作(≤70 mg/dL和/或需要护理)。9.4%的安慰剂患者、10.2%的恩帕列嗪10 mg患者和8.3%的恩帕列嗪25 mg患者出现尿路感染。据报道,服用安慰剂的1.0%患者、服用10mg的4.6%患者和服用25mg的3.5%患者出现生殖器感染。结论与安慰剂相比,服用其他口服治疗的恩帕列嗪可降低HbA1c、体重和SBP/DBP,具有良好的安全性和耐受性。
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引用次数: 3
Bariatric surgery results in patients with type 1 diabetes mellitus on continuous subcutaneous insulin infusion therapy 持续皮下胰岛素输注治疗1型糖尿病患者的减肥手术结果
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.09.014
Jesus Moreno-Fernandez , Ana Chico , on behalf of the Working Group of Diabetes and Technology of the Spanish Diabetes Association, Spain
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引用次数: 3
Healthcare costs of people with type 2 diabetes mellitus in the Basque Country (Spain) 巴斯克地区2型糖尿病患者的医疗费用(西班牙)
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.11.002
Roberto Nuño-Solinís , Edurne Alonso-Morán , Jose M. Arteagoitia Axpe , Patxi Ezkurra Loiola , Juan F. Orueta , Sonia Gaztambide

Objective

The aim of the study was to estimate the direct costs of healthcare provided to patients with type 2 diabetes mellitus (T2DM) in the Basque Country and to compare them with those of the population with chronic diseases.

Material and methods

A retrospective, cross-sectional, population-based study. Direct healthcare costs for patients aged over 35 years diagnosed with T2DM in the Basque Country (n = 126,894) were calculated, stratified by age, sex and deprivation index, and compared to the costs for the population diagnosed with a chronic disease other than T2DM (n = 1,347,043).

Results

The annual average healthcare cost of a person with T2DM was €3432. Cost gradually increased with age to €4313 in patients aged 80–84 years. Cost in males were €161 higher as compared to costs in females (P < 0.001). In the most socioeconomically disadvantaged areas, cost per patient was €468 (14.9%) greater than in the most privileged areas (P < 0.001). Moreover, cost was 68.5% higher (P < 0.001) for patients with T2DM than for patients with other chronic diseases. Total annual direct costs amounted to €435.5 million, or 12.78% of total public health expenditure in the region.

Conclusions

Direct mean healthcare costs in the Basque Country for patients with T2DM were higher in males, in the most underprivileged areas, in patients with comorbidities, and in older age groups, and represented €3432 per person per year.

目的本研究的目的是估计巴斯克地区2型糖尿病(T2DM)患者的直接医疗费用,并将其与慢性病患者的医疗费用进行比较。材料和方法一项回顾性、横断面、基于人群的研究。计算了巴斯克地区35岁以上被诊断为2型糖尿病患者(n=126894)的直接医疗费用,并按年龄、性别和剥夺指数进行了分层,并与被诊断为除2型糖尿病以外的慢性病的人群(n=1347043)的费用进行了比较。随着年龄的增长,80-84岁患者的费用逐渐增加,达到4313欧元。男性的成本比女性高161欧元(P<;0.001)。在社会经济最贫困的地区,每位患者的成本比最优惠的地区高468欧元(14.9%)。此外,T2DM患者的成本也比其他慢性病患者高68.5%(P<!0.001)。年度直接费用总额达4.355亿欧元,占该地区公共卫生支出总额的12.78%。结论巴斯克地区男性、最贫困地区、合并症患者和老年组T2DM患者的直接平均医疗费用较高,为每人每年3432欧元。
{"title":"Healthcare costs of people with type 2 diabetes mellitus in the Basque Country (Spain)","authors":"Roberto Nuño-Solinís ,&nbsp;Edurne Alonso-Morán ,&nbsp;Jose M. Arteagoitia Axpe ,&nbsp;Patxi Ezkurra Loiola ,&nbsp;Juan F. Orueta ,&nbsp;Sonia Gaztambide","doi":"10.1016/j.endoen.2016.11.002","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.11.002","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of the study was to estimate the direct costs of healthcare provided to patients with type 2 diabetes mellitus (T2DM) in the Basque Country and to compare them with those of the population with chronic diseases.</p></div><div><h3>Material and methods</h3><p>A retrospective, cross-sectional, population-based study. Direct healthcare costs for patients aged over 35 years diagnosed with T2DM in the Basque Country (n<!--> <!-->=<!--> <!-->126,894) were calculated, stratified by age, sex and deprivation index, and compared to the costs for the population diagnosed with a chronic disease other than T2DM (n<!--> <!-->=<!--> <!-->1,347,043).</p></div><div><h3>Results</h3><p>The annual average healthcare cost of a person with T2DM was €3432. Cost gradually increased with age to €4313 in patients aged 80–84 years. Cost in males were €161 higher as compared to costs in females (<em>P</em> <!-->&lt;<!--> <!-->0.001). In the most socioeconomically disadvantaged areas, cost per patient was €468 (14.9%) greater than in the most privileged areas (<em>P</em> <!-->&lt;<!--> <!-->0.001). Moreover, cost was 68.5% higher (<em>P</em> <!-->&lt;<!--> <!-->0.001) for patients with T2DM than for patients with other chronic diseases. Total annual direct costs amounted to €435.5 million, or 12.78% of total public health expenditure in the region.</p></div><div><h3>Conclusions</h3><p>Direct mean healthcare costs in the Basque Country for patients with T2DM were higher in males, in the most underprivileged areas, in patients with comorbidities, and in older age groups, and represented €3432 per person per year.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 10","pages":"Pages 543-550"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72055993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Impact of diabetes education on type 1 diabetes mellitus control in children 糖尿病教育对儿童1型糖尿病控制的影响
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.08.012
Daniel E. Alonso Martín, M. Belén Roldán Martín, M. Ángeles Álvarez Gómez, Rosa Yelmo Valverde, María Martín-Frías, Milagros Alonso Blanco, Raquel Barrio Castellanos

Introduction

Diabetes education is an essential tool to achieve treatment objectives in type 1 diabetes mellitus (T1DM). The aim of this study was to determine if understanding of diabetes by caregivers/patients or sociodemographic factors affect blood glucose control in children and adolescents with T1DM.

Patients and methods

The level of knowledge of 105 caregivers of children and adolescents with T1DM was assessed using a survey adapted to the type of treatment used (multiple dose insulin [MDI] or continuous subcutaneous insulin infusion [CSII]). Mean HbA1c levels in the previous year was considered as metabolic control marker.

Results

Mean HbA1c levels were similar in both treatment groups, with slightly higher values in children over 12 years of age. Patients on CSII had a longer time since disease onset and had poorer results, maybe because the items were more difficult due to the higher level of knowledge required for this treatment modality (p = 0.005). Caregivers with lower educational levels achieved poorer scores in the survey, but mean HbA1c levels of their children were lower, probably because of their greater involvement in disease care.

Conclusions

The level of knowledge of caregivers and/or patients with T1DM was high, and this was associated to good metabolic control. Studies to assess the impact of caregiver knowledge on metabolic control of children are needed.

引言糖尿病教育是实现1型糖尿病(T1DM)治疗目标的重要工具。这项研究的目的是确定照顾者/患者对糖尿病的理解或社会人口统计学因素是否会影响患有T1DM的儿童和青少年的血糖控制。患者和方法105名患有T1DM儿童和青少年照顾者的知识水平通过一项适用于所用治疗类型的调查(多剂量胰岛素[MDI]或连续皮下胰岛素输注[CSI])。前一年的平均HbA1c水平被认为是代谢控制标志。结果两个治疗组的平均HbA1c水平相似,12岁以上儿童的HbA1c值略高。CSII患者自发病以来的时间较长,结果较差,可能是因为这种治疗方式所需的知识水平较高,项目更难(p=0.005)。教育水平较低的护理人员在调查中得分较差,但他们孩子的平均HbA1c水平较低,可能是因为他们更多地参与疾病护理。结论照顾者和/或T1DM患者的知识水平较高,这与良好的代谢控制有关。需要进行研究以评估护理人员知识对儿童代谢控制的影响。
{"title":"Impact of diabetes education on type 1 diabetes mellitus control in children","authors":"Daniel E. Alonso Martín,&nbsp;M. Belén Roldán Martín,&nbsp;M. Ángeles Álvarez Gómez,&nbsp;Rosa Yelmo Valverde,&nbsp;María Martín-Frías,&nbsp;Milagros Alonso Blanco,&nbsp;Raquel Barrio Castellanos","doi":"10.1016/j.endoen.2016.08.012","DOIUrl":"https://doi.org/10.1016/j.endoen.2016.08.012","url":null,"abstract":"<div><h3>Introduction</h3><p>Diabetes education is an essential tool to achieve treatment objectives in type 1 diabetes mellitus (T1DM). The aim of this study was to determine if understanding of diabetes by caregivers/patients or sociodemographic factors affect blood glucose control in children and adolescents with T1DM.</p></div><div><h3>Patients and methods</h3><p>The level of knowledge of 105 caregivers of children and adolescents with T1DM was assessed using a survey adapted to the type of treatment used (multiple dose insulin [MDI] or continuous subcutaneous insulin infusion [CSII]). Mean HbA1c levels in the previous year was considered as metabolic control marker.</p></div><div><h3>Results</h3><p>Mean HbA1c levels were similar in both treatment groups, with slightly higher values in children over 12<!--> <!-->years of age. Patients on CSII had a longer time since disease onset and had poorer results, maybe because the items were more difficult due to the higher level of knowledge required for this treatment modality (<em>p</em> <!-->=<!--> <!-->0.005). Caregivers with lower educational levels achieved poorer scores in the survey, but mean HbA1c levels of their children were lower, probably because of their greater involvement in disease care.</p></div><div><h3>Conclusions</h3><p>The level of knowledge of caregivers and/or patients with T1DM was high, and this was associated to good metabolic control. Studies to assess the impact of caregiver knowledge on metabolic control of children are needed.</p></div>","PeriodicalId":48670,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 10","pages":"Pages 536-542"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endoen.2016.08.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72055995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Gut microbiota and type 2 diabetes mellitus 肠道微生物群与2型糖尿病
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.07.004
Araceli Muñoz-Garach, Cristina Diaz-Perdigones, Francisco J. Tinahones

In recent years, many studies have related gut microbiome to development of highly prevalent diseases such as type 2 diabetes and obesity. Obesity itself is associated to changes in the composition of gut microbiome, with a trend to an overgrowth of microorganisms more efficiently obtaining energy from diet. There are several mechanisms that relate microbiota to the onset of insulin resistance and diabetes, including changes in bowel permeability, endotoxemia, interaction with bile acids, changes in the proportion of brown adipose tissue, and effects associated to use of drugs like metformin.

Currently, use of pro and prebiotics and other new techniques such as gut microbiota transplant, or even antibiotic therapy, has been postulated to be useful tools to modulate the development of obesity and insulin resistance through the diet.

近年来,许多研究将肠道微生物组与2型糖尿病和肥胖症等高度流行疾病的发展联系起来。肥胖本身与肠道微生物组组成的变化有关,微生物有过度生长的趋势,可以更有效地从饮食中获得能量。有几种机制将微生物群与胰岛素抵抗和糖尿病的发作联系起来,包括肠道通透性的变化、内毒素血症、与胆汁酸的相互作用、棕色脂肪组织比例的变化,以及与二甲双胍等药物使用相关的影响。目前,益生元和益生元的使用以及其他新技术,如肠道微生物群移植,甚至抗生素治疗,被认为是通过饮食调节肥胖和胰岛素抵抗发展的有用工具。
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引用次数: 71
Cardiovascular risk factors in scholars (RIVACANGAS) 学者心血管危险因素(RIVANGAS)
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.07.003
Rocío Mera-Gallego , Patricia García-Rodríguez , Marta Fernández-Cordeiro , Ángeles Rodríguez-Reneda , Natalia Vérez-Cotelo , N. Floro Andrés-Rodríguez , J. Antonio Fornos-Pérez , Itxaso Rica-Echevarría

Background and aim

The current guidelines for treatment of high blood pressure do not include any section dedicated to hypertension in children and adolescents or to cardiovascular disease (CVD) prevention strategies in that age group. Our study was aimed at identifying cardiovascular risk factors (CVRFs) in an adolescent sample.

Subjects and methods

A cross-sectional study of a sample of adolescents aged 12–17 years (n = 630), conducted from October 2014 to February 2015 in four schools in Cangas do Morrazo (Pontevedra). Sociodemographic variables: age, sex, personal and family history of hypertension and diabetes (DM). Anthropometric variables: body mass index (BMI, kg/m2), waist circumference (WC, cm), waist/height index (WHI), blood pressure (mmHg).

Results

The study sample consisted of 295 female and 335 male adolescents (mean age: 13.8 ± 1.4). CVR-related conditions: hypercholesterolemia (7.1%), CVD (1.7%), hypertension (0.8%) and diabetes (0.3%). BMI (22.0 ± 3,8) was higher in males (22.4 ± 3.8 vs 21.0 ± 3.2; p < .01). Overweight was greater in females (27.6% vs 19.7%; p < .05). Seven percent of subjects were obese, 63.8% had systolic BP > P90 and 23.7% had diastolic BP > P90.

Waist circumference positively correlated with age (r = 0.1669; p < .0001) and was greater in males (75.4 ± 10.9 vs 72.9 ± 8.9; p < 0.01); 27.1% of adolescents had a waist circumference > P75, and 7.5% > P90. Eighty-four (13.3%) adolescents had two CVRFs (overweight + another).

Conclusions

Despite their young age, more than 10% of school children had two CVRFs. Abnormal SBP levels were seen in more than 50%, 20% were overweight, and only 75% had normal waist circumference values.

背景和目的目前的高血压治疗指南没有包括任何专门针对儿童和青少年高血压或该年龄组心血管疾病(CVD)预防策略的章节。我们的研究旨在确定青少年样本中的心血管危险因素(CVRF)。受试者和方法2014年10月至2015年2月在Cangas do Morrazo(Pontevedra)的四所学校对12-17岁青少年(n=630)进行的横断面研究。社会人口学变量:年龄、性别、高血压和糖尿病的个人和家族史。人体测量变量:体重指数(BMI,kg/m2)、腰围(WC,cm)、腰围/身高指数(WHI)、血压(mmHg)。结果研究样本包括295名女性和335名男性青少年(平均年龄:13.8±1.4)。CVR相关疾病:高胆固醇血症(7.1%)、心血管疾病(1.7%)、高血压(0.8%)和糖尿病(0.3%)。男性的BMI(22.0±3.8)更高(22.4±3.8 vs 21.0±3.2;p<;.01)。女性超重更大(27.6%vs 19.7%;p&lgt;.05)。7%的受试者肥胖,63.8%的患者收缩压>;P90和23.7%的患者具有舒张压>;P90.腰围与年龄呈正相关(r=0.1669;p<;.0001),男性腰围更大(75.4±10.9 vs 72.9±8.9;p&llt;0.01);27.1%的青少年的腰围>;P75和7.5%>;P90.84名(13.3%)青少年有两次CVRF(超重+另一次)。结论10%以上的在校儿童在幼年时期有两次CVRF。超过50%的患者SBP水平异常,20%的患者超重,只有75%的患者腰围值正常。
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引用次数: 1
Impact of obesity on bone metabolism 肥胖对骨代谢的影响
Pub Date : 2016-12-01 DOI: 10.1016/j.endoen.2016.08.013
Juan J. López-Gómez , José L. Pérez Castrillón , Daniel A. de Luis Román

High weight is a protective factor against osteoporosis and risk of fracture. In obesity, however, where overweight is associated to excess fat, this relationship does not appear to be so clear, excess weight has sometimes been associated to decreased bone mass. Obesity interferes with bone metabolism through mechanical, hormonal, and inflammatory factors. These factors are closely related to weight, body composition, and dietary patterns of these patients. The net beneficial or harmful effect on bone mass or risk of fracture of the different components of this condition is not well known. We need to recognize patients at a greater risk of bone disease related to obesity to start an adequate intervention.

高体重是预防骨质疏松症和骨折风险的一个保护因素。然而,在肥胖中,超重与脂肪过多有关,这种关系似乎并不那么明确,超重有时与骨量减少有关。肥胖通过机械、激素和炎症因素干扰骨代谢。这些因素与这些患者的体重、身体成分和饮食模式密切相关。这种情况的不同组成部分对骨量或骨折风险的净有益或有害影响尚不清楚。我们需要认识到与肥胖相关的骨病风险更大的患者,以便开始适当的干预。
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引用次数: 28
期刊
Endocrinologia Y Nutricion
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