天然抗菌肽有望成为抗HIV候选药物。

Q4 Biochemistry, Genetics and Molecular Biology Current Topics in Peptide and Protein Research Pub Date : 2012-01-01
Guangshun Wang
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引用次数: 0

摘要

人类免疫缺陷病毒1型(HIV-1)感染仍然是全球主要的健康问题之一。因此,有必要鉴定新的治疗分子来对抗HIV-1。天然抗菌肽(AMP)已被认为是开发局部杀微生物剂的有前途的模板。这篇综述系统地讨论了抗菌肽数据库中注释的80多种抗HIV肽(http://aps.unmc.edu/AP)。这种肽是从细菌、植物和动物身上发现的。实例包括来自细菌的gramicidin和细菌素、来自植物的cyclotides、来自昆虫的蜂毒肽和盲肠素、来自鱼类的豆酸素、蛔虫素、盲肠素、皮蛋白酶素、esculentin和maximins,以及来自脊椎动物的cathelicidins和防御素。这些肽似乎通过不同的机制发挥作用,并可以通过多种方式阻断病毒进入。作为额外的优点,这种抗HIV肽可以具有其他所需的特征,例如抗菌、抗寄生虫、杀精子和抗癌活性。随着肽稳定性、生产、配方和递送方法的不断优化,预计其中一些化合物最终可能成为新的抗HIV药物。
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Natural antimicrobial peptides as promising anti-HIV candidates.

Human immunodeficiency virus type 1 (HIV-1) infection remains to be one of the major global health problems. It is thus necessary to identify novel therapeutic molecules to combat HIV-1. Natural antimicrobial peptides (AMPs) have been recognized as promising templates for developing topical microbicides. This review systematically discusses over 80 anti-HIV peptides annotated in the antimicrobial peptide database (http://aps.unmc.edu/AP). Such peptides have been discovered from bacteria, plants, and animals. Examples include gramicidin and bacteriocins from bacteria, cyclotides from plants, melittins and cecropins from insects, piscidins from fish, ascaphins, caerins, dermaseptins, esculentins, and maximins from amphibians, and cathelicidins and defensins from vertebrates. These peptides appear to work by different mechanisms and could block viral entry in multiple ways. As additional advantages, such anti-HIV peptides may possess other desired features such as antibacterial, antiparasital, spermicidal, and anticancer activity. With continued optimization of peptide stability, production, formulation and delivery methods, it is anticipated that some of these compounds may eventually become new anti-HIV drugs.

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来源期刊
Current Topics in Peptide and Protein Research
Current Topics in Peptide and Protein Research Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
0.60
自引率
0.00%
发文量
1
期刊介绍: Current Topics in Peptide & Protein Research provides a medium for the publication of review articles and original research papers on various aspects of peptide and protein Research. It covers all aspects of amino acid, peptide, peptidomimetic, and protein science, including chemical, biophysical, biological and pharmaceutical aspects.
期刊最新文献
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