生物工程皮肤替代品在燃烧学中的应用前景(文献综述)

S. G. Shapovalov, A. V. Kcheuso, T. E. Koshelev, D. K. Savchenkov
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引用次数: 0

摘要

的相关性。尽管科学技术的进步和治疗方法的改进,但对皮肤热烧伤的辅助治疗仍然是一个复杂的多组分问题。大面积的深度烧伤不能自愈,因此,在过去的一个世纪里,自体皮肤成形术已经成为标准的治疗方法。然而,由于患者健康组织的短缺,通常不能完全进行移植,这就需要寻找替代自身组织的选择。介绍生物工程皮肤替代品在微生物学中的应用的现代可能性和问题。利用PubMed数据库和科学电子图书馆(eLIBRARY.ru)平台检索近年来发表的科学文献资源。结果和讨论。目前,已经开发了许多皮肤替代品,从单层组织等效物到人造皮革和转基因替代品。然而,它们都还远远不够完善,它们各有优缺点,这决定了它们的应用特点,需要进一步的研究。皮肤组织等效物的发展显著改善了深度烧伤患者的治疗效果,是现代燃烧学发展的一个有希望的方向。
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The possibilities of using bioengineered skin substitutes in combustiology (literature review)
Relevance. Despite scientific and technological progress and improvement of treatment methods, providing assistance for thermal burns of the skin remains a complex multicomponent problem. Extensive deep burns are not capable of self-healing, and therefore, over the past century, autodermoplasty has become the standard method of treatment. However, the shortage of healthy tissues of the patient often does not allow the transplantation to be performed in full, which entails the need to search for options for replacing auto-tissues.Intention. To present modern possibilities and evaluate the problems of using bioengineered skin substitutes in kombustiology.Methodology. Scientific literary sources published in recent years were searched for using the PubMed database and the platform of Scientific Electronic Library (eLIBRARY.ru ).Results and Discussion. Currently, many skin substitutes have been developed, ranging from single-layer tissue equivalents to artificial leather and genetically modified substitutes. However, all of them are still far from perfect, they have their advantages and disadvantages, which determine the features of their application and necessitate further research.Conclusion. The development of tissue equivalents of the skin has significantly improved the results of treatment of victims with deep burns and is a promising direction in the development of modern combustiology.
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CiteScore
0.80
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0.00%
发文量
28
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