Optimization of Preparation Process of Hydroxypropyl-beta-Cyclodextrin by Response Surface Methodology

The preparation process of hydroxypropyl-β-cyclodextrin was optimized to the degree of substitution and recovery in this study. A central composite design of response surface methodology involving reaction time, reaction temperature, dialysis time was used, and second-order model for the yeild was employed to generate the response surface. The optimum condition for the preparation process was determined as follows: reaction time 16.05 h, reaction temperature 31.06 °C, dialysis time 7.41 h. The obtained degree of substitution and recovery at the optimum condition were 4.10 and 60.23%.