Hygienic regulation of the antiretroviral drug tenofovir in the air of the working area

Introduction. Tenofovir is an antiviral drug of the group of nucleoside reverse transcriptase inhibitors of retrovirus - human immunodeficiency virus. Material and methods. A toxicological and hygienic study of the toxicity and danger of tenofovir in laboratory animals (mice, rats, rabbits) was carried out with various routes of intake: orally (mice, rats), intraperitoneally (mice), cutaneous (mice, rabbits), inhalation (rats) for development and justification of indicative limit values of tenofovir in the air of the working area. Results. When injected into the stomach, tenofovir belongs to the 4th hazard class in terms of DL50 for mice and rats over 10,000 mg/kg (GOST 12.1.007-76). When injected into the abdominal cavity DL50 for male mice 1443 mg/kg (OECD toxicity class 5). Tenofovir has a moderate irritant effect on the mucous membranes of the eyes of rabbits, does not irritate the skin; does not have a skin-resorptive, cumulative and sensitizing effect. In a subacute experiment in rats with intragastric administration (1000 mg/kg, 28 days), tenofovir had a general toxic effect with a predominant impairment of kidney and liver function. Tenofovir Limac is set at 17.3 mg/m3 for effects on renal function. Limitations. When developing and substantiating hygienic standards for the anti-retroviral drug tenofovir in the air of the working area. Conclusion. The recommended indicative limit values for tenofovir disoproxil fumarate aerosol in the air of the working area is 0.1 mg/m3.