{"title":"DNA修复在结核分枝杆菌发病机制中的作用","authors":"Digby F. Warner","doi":"10.1016/j.ddmec.2010.08.002","DOIUrl":null,"url":null,"abstract":"<div><p><span><em>Mycobacterium tuberculosis</em></span> is exposed to multiple genotoxic stresses during host infection. Although crucial for bacillary survival and strain evolution, including the emergence of drug resistance, the mechanisms governing genome maintenance and DNA damage tolerance in <em>M. tuberculosis</em> remain poorly understood. This review highlights evidence for the roles of the major DNA repair pathways in mycobacterial pathogenesis and considers their potential identification as targets for novel compounds, especially those designed to inhibit the evolution of resistance.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e5-e11"},"PeriodicalIF":0.0000,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.08.002","citationCount":"12","resultStr":"{\"title\":\"The role of DNA repair in M. tuberculosis pathogenesis\",\"authors\":\"Digby F. Warner\",\"doi\":\"10.1016/j.ddmec.2010.08.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><em>Mycobacterium tuberculosis</em></span> is exposed to multiple genotoxic stresses during host infection. Although crucial for bacillary survival and strain evolution, including the emergence of drug resistance, the mechanisms governing genome maintenance and DNA damage tolerance in <em>M. tuberculosis</em> remain poorly understood. This review highlights evidence for the roles of the major DNA repair pathways in mycobacterial pathogenesis and considers their potential identification as targets for novel compounds, especially those designed to inhibit the evolution of resistance.</p></div>\",\"PeriodicalId\":72843,\"journal\":{\"name\":\"Drug discovery today. Disease mechanisms\",\"volume\":\"7 1\",\"pages\":\"Pages e5-e11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.08.002\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug discovery today. Disease mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1740676510000192\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676510000192","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The role of DNA repair in M. tuberculosis pathogenesis
Mycobacterium tuberculosis is exposed to multiple genotoxic stresses during host infection. Although crucial for bacillary survival and strain evolution, including the emergence of drug resistance, the mechanisms governing genome maintenance and DNA damage tolerance in M. tuberculosis remain poorly understood. This review highlights evidence for the roles of the major DNA repair pathways in mycobacterial pathogenesis and considers their potential identification as targets for novel compounds, especially those designed to inhibit the evolution of resistance.
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